Seroatlas · Human Serome Atlas

BTG2

Protein BTG2

Also known as: APRO1, BTG2_HUMAN, MGC126063, MGC126064, PC3, TIS21

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P78543
Gene: BTG2
Ensembl: ENSG00000159388
Chromosome: 1
Canonical length: 158 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

158 residues, UniProt reviewed canonical sequence.

>P78543|BTG2
     1  MSHGKGTDML PEIAAAVGFL SSLLRTRGCV SEQRLKVFSG ALQEALTEHY KHHWFPEKPS
    61  KGSGYRCIRI NHKMDPIISR VASQIGLSQP QLHQLLPSEL TLWVDPYEVS YRIGEDGSIC
   121  VLYEEAPLAA SCGLLTCKNQ VLLGRSSPSK NYVMAVSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BTG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 461 nTPM

Expression across tissuesHPA

Tissue

pancreas: 461 nTPM
ovary: 377 nTPM
thymus: 312 nTPM
esophagus: 295 nTPM
bone marrow: 292 nTPM
tongue: 268 nTPM

Single-cell type

urothelial cells: 1,394 nCPM
neutrophils: 1,237 nCPM
smooth muscle cells: 1,232 nCPM
thymic myoid cells: 1,221 nCPM
pancreatic acinar cells: 1,186 nCPM
epididymal basal cells: 1,166 nCPM

Immune cell

neutrophil: 77 nTPM
plasmacytoid DC: 39 nTPM
non-classical monocyte: 36 nTPM
memory B-cell: 30 nTPM
naive B-cell: 29 nTPM
intermediate monocyte: 27 nTPM

Brain region

medulla oblongata: 86 nTPM
cerebellum: 76 nTPM
spinal cord: 60 nTPM
hypothalamus: 59 nTPM
pons: 46 nTPM
thalamus: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0.02
gnomAD missense Z: 0.72
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transcription corepressor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BTG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BTG2 as an antibody target. Whether an autoantibody or antibody against BTG2 could matter depends on whether native BTG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BTG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BTG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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