IFNAR1

Protein identityUniProt · HPA

UniProt accession

P17181

Gene

IFNAR1

Ensembl

ENSG00000142166

Chromosome

21

Canonical length

557 aa

Protein class

Cancer-related genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family and functions as an antiviral factor. [provided by RefSeq, Jul 2020]

Canonical amino-acid sequenceUniProt

557 residues, UniProt reviewed canonical sequence.

>P17181|IFNAR1
     1  MMVVLLGATT LVLVAVAPWV LSAAAGGKNL KSPQKVEVDI IDDNFILRWN RSDESVGNVT
    61  FSFDYQKTGM DNWIKLSGCQ NITSTKCNFS SLKLNVYEEI KLRIRAEKEN TSSWYEVDSF
   121  TPFRKAQIGP PEVHLEAEDK AIVIHISPGT KDSVMWALDG LSFTYSLVIW KNSSGVEERI
   181  ENIYSRHKIY KLSPETTYCL KVKAALLTSW KIGVYSPVHC IKTTVENELP PPENIEVSVQ
   241  NQNYVLKWDY TYANMTFQVQ WLHAFLKRNP GNHLYKWKQI PDCENVKTTQ CVFPQNVFQK
   301  GIYLLRVQAS DGNNTSFWSE EIKFDTEIQA FLLPPVFNIR SLSDSFHIYI GAPKQSGNTP
   361  VIQDYPLIYE IIFWENTSNA ERKIIEKKTD VTVPNLKPLT VYCVKARAHT MDEKLNKSSV
   421  FSDAVCEKTK PGNTSKIWLI VGICIALFAL PFVIYAAKVF LRCINYVFFP SLKPSSSIDE
   481  YFSEQPLKNL LLSTSEEQIE KCFIIENIST IATVEETNQT DEDHKKYSSQ TSQDSGNYSN
   541  EDESESKTSE ELQQDFV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFNAR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

32 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IFNAR1.

Disease | AllUniProt

Conditions IFNAR1 is implicated in, by any mechanism.

• Immunodeficiency 106, susceptibility to viral infections (IMD106) MIM:619935

Disease | GeneticClinVar

23 pathogenic / likely-pathogenic of 366 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Immunodeficiency 106, susceptibility to viral infections

ReferencesPubMed · IEDB

Publications for IFNAR1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.21

gnomAD pLI

0

gnomAD missense Z

0.36

DepMap mean gene effect

0.17

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell surface receptor signaling pathway via JAK-STAT
• cellular response to interferon-alpha
• cellular response to interferon-beta
• cellular response to virus
• positive regulation of cellular respiration
• response to lipopolysaccharide
• response to virus
• type I interferon-mediated signaling pathway

Molecular functions

• cytokine binding
• JAK pathway signal transduction adaptor activity
• type I interferon binding
• type I interferon receptor activity

Cellular components

• late endosome
• lysosome
• plasma membrane
• receptor complex

Protein domainsUniProt · Pfam · InterPro

• Fibronectin type III
• Immunoglobulin-like fold
• Interferon/interleukin receptor domain
• Fibronectin type III superfamily
• Tissue factor
• Interferon-alpha/beta receptor, fibronectin type III
• Interferon alpha/beta receptor 1

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Endosome
• Glycoprotein
• Isopeptide bond
• Lipoprotein
• Lysosome
• Membrane
• Palmitate
• Phosphoprotein
• Receptor
• Repeat
• Signal
• Transmembrane
• Transmembrane helix
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of IFNAR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SHMT2
• STAT1
• STAT2
• TRIM10
• TYK2
• PRMT1
• FBXW11