Seroatlas · Human Serome Atlas

HABP4

Intracellular hyaluronan-binding protein 4

Also known as: HABP4_HUMAN, IHABP4, SERBP1L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5JVS0
Gene
HABP4
Ensembl
ENSG00000130956
Chromosome
9
Canonical length
413 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear membrane,Cytosol

OverviewNCBI Gene

Enables SUMO binding activity. Involved in PML body organization; positive regulation of RNA splicing; and positive regulation of translational initiation. Located in several cellular components, including cytoplasmic stress granule; nuclear lumen; and nuclear membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

413 residues, UniProt reviewed canonical sequence.

>Q5JVS0|HABP4
     1  MKGALGSPVA AAGAAMQESF GCVVANRFHQ LLDDESDPFD ILREAERRRQ QQLQRKRRDE
    61  AAAAAGAGPR GGRSPAGASG HRAGAGGRRE SQKERKSLPA PVAQRPDSPG GGLQAPGQKR
   121  TPRRGEQQGW NDSRGPEGML ERAERRSYRE YRPYETERQA DFTAEKFPDE KPGDRFDRDR
   181  PLRGRGGPRG GMRGRGRGGP GNRVFDAFDQ RGKREFERYG GNDKIAVRTE DNMGGCGVRT
   241  WGSGKDTSDV EPTAPMEEPT VVEESQGTPE EESPAKVPEL EVEEETQVQE MTLDEWKNLQ
   301  EQTRPKPEFN IRKPESTVPS KAVVIHKSKY RDDMVKDDYE DDSHVFRKPA NDITSQLEIN
   361  FGNLPRPGRG ARGGTRGGRG RIRRAENYGP RAEVVMQDVA PNPDDPEDFP ALS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HABP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
110 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 110 nTPM
  • cerebral cortex: 102 nTPM
  • amygdala: 90 nTPM
  • midbrain: 78 nTPM
  • hippocampal formation: 75 nTPM
  • hypothalamus: 72 nTPM

Single-cell type

  • late spermatids: 1,345 nCPM
  • early spermatids: 310 nCPM
  • retinal ganglion cells: 104 nCPM
  • vascular smooth muscle cells: 76 nCPM
  • retinal amacrine cells: 75 nCPM
  • late primary spermatocytes: 73 nCPM

Immune cell

  • memory B-cell: 1.9 nTPM
  • memory CD4 T-cell: 1.6 nTPM
  • memory CD8 T-cell: 1.3 nTPM
  • T-reg: 1.3 nTPM
  • naive B-cell: 1.1 nTPM
  • naive CD4 T-cell: 1.1 nTPM

Brain region

  • cerebral cortex: 84 nTPM
  • basal ganglia: 81 nTPM
  • white matter: 77 nTPM
  • medulla oblongata: 74 nTPM
  • midbrain: 73 nTPM
  • pons: 73 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0.01
gnomAD missense Z
1.13
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HABP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HABP4 as an antibody target. Whether an autoantibody or antibody against HABP4 could matter depends on whether native HABP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HABP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HABP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HABP4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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