Seroatlas · Human Serome Atlas

TCP11

T-complex protein 11 homolog

Also known as: D6S230E, FPPR, KIAA0229, TCP11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WWU5
Gene: TCP11
Ensembl: ENSG00000124678
Chromosome: 6
Canonical length: 503 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Involved in germ cell development. Located in acrosomal vesicle and sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

503 residues, UniProt reviewed canonical sequence.

>Q8WWU5|TCP11
     1  MPDVKESVPP KYPGDSEGRS CKPETSGPPQ EDKSGSEDPP PFLSVTGLTE TVNEVSKLSN
    61  KIGMNCDYYM EEKVLPPSSL EGKVKETVHN AFWDHLKEQL SATPPDFSCA LELLKEIKEI
   121  LLSLLLPRQN RLRIEIEEAL DMDLLKQEAE HGALKVLYLS KYVLNMMALL CAPVRDEAVQ
   181  KLENITDPVW LLRGIFQVLG RMKMDMVNYT IQSLQPHLQE HSIQYERAKF QELLNKQPSL
   241  LNHTTKWLTQ AAGDLTMSPP TCPDTSDSSS VAGPSPNEAA NNPEPLSPTM VLCQGFLNLL
   301  LWDLENEEFP ETLLMDRTRL QELKSQLHQL TVMASVLLVA SSFSGSVLFG SPQFVDKLKR
   361  ITKSLLEDFH SRPEEAILTV SEQVSQEIHQ SLKNMGLVAL SSDNTASLMG QLQNIAKKEN
   421  CVCSVIDQRI HLFLKCCLVL GVQRSLLDLP GGLTLIEAEL AELGQKFVNL THHNQQVFGP
   481  YYTEILKTLI SPAQALETKV ESV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCP11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 328 nTPM

Expression across tissuesHPA

Tissue

testis: 328 nTPM
fallopian tube: 0.9 nTPM
epididymis: 0.7 nTPM
ovary: 0.7 nTPM
kidney: 0.5 nTPM
breast: 0.4 nTPM

Single-cell type

late spermatids: 11,780 nCPM
early spermatids: 1,999 nCPM
late primary spermatocytes: 1,360 nCPM
early primary spermatocytes: 80 nCPM
sertoli cells: 27 nCPM
undifferentiated spermatogonia: 19 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.6 nTPM
white matter: 0.6 nTPM
amygdala: 0.5 nTPM
basal ganglia: 0.5 nTPM
hippocampal formation: 0.5 nTPM
hypothalamus: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: 0.87
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TCP11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCP11 as an antibody target. Whether an autoantibody or antibody against TCP11 could matter depends on whether native TCP11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCP11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCP11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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