Seroatlas · Human Serome Atlas

TBC1D31

TBC1 domain family member 31

Also known as: Gm85, MGC21654, TBC31_HUMAN, WDR67

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DN5
Gene: TBC1D31
Ensembl: ENSG00000156787
Chromosome: 8
Canonical length: 1066 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centrosome,Basal body

OverviewNCBI Gene

Enables molecular adaptor activity. Involved in cilium assembly. Located in Golgi apparatus; centriolar satellite; and ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1066 residues, UniProt reviewed canonical sequence.

>Q96DN5|TBC1D31
     1  MQSTDLGNKE SGKIWHRKPS PATRDGIIVN IIHNTSDYHP KVLRFLNVAF DGTGDCLIAG
    61  DHQGNIYVFD LHGNRFNLVQ RTAQACTALA FNLRRKSEFL VALADYSIKC FDTVTKELVS
   121  WMRGHESSVF SISVHASGKY AITTSSDTAQ LWDLDTFQRK RKLNIRQSVG IQKVFFLPLS
   181  NTILSCFKDN SIFAWECDTL FCKYQLPAPP ESSSILYKVF AVTRDGRILA AGGKSNHLHL
   241  WCLEARQLFR IIQMPTKVRA IRHLEFLPDS FDAGSNQVLG VLSQDGIMRF INMQTCKLLF
   301  EIGSLDEGIS SSAISPHGRY IASIMENGSL NIYSVQALTQ EINKPPPPLV KVIEDLPKNK
   361  LSSSDLKMKV TSGRVQQPAK SRESKMQTRI LKQDLTGDFE SKKNELPDGL NKKRLQILLK
   421  GYGEYPTKYR MFIWRSLLQL PENHTAFSTL IDKGTHVAFL NLQKKYPIKS RKLLRVLQRT
   481  LSALAHWSVI FSDTPYLPLL AFPFVKLFQN NQLICFEVIA TLIINWCQHW FEYFPNPPIN
   541  ILSMIENVLA FHDKELLQHF IDHDITSQLY AWPLLETVFS EVLTREEWLK LFDNIFSNHP
   601  SFLLMTVVAY NICSRTPLLS CNLKDDFEFF FHHRNNLDIN VVIRQVYHLM ETTPTDIHPD
   661  SMLNVFVALT KGQYPVFNQY PKFIVDYQTQ ERERIRNDEL DYLRERQTVE DMQAKVDQQR
   721  VEDEAWYQKQ ELLRKAEETR REMLLQEEEK MIQQRQRLAA VKRELKVKEM HLQDAARRRF
   781  LKLQQDQQEM ELRRLDDEIG RKVYMRDREI AATARDLEMR QLELESQKRL YEKNLTENQE
   841  ALAKEMRADA DAYRRKVDLE EHMFHKLIEA GETQSQKTQK VIKENLAKAE QACLNTDWQI
   901  QSLHKQKCDD LQRNKCYQEV AKLLRENRRK EIEIINAMVE EEAKKWKEAE GKEFRLRSAK
   961  KASALSDASR KWFLKQEINA AVEHAENPCH KEEPRFQNEQ DSSCLPRTSQ LNDSSEMDPS
  1021  TQISLNRRAV EWDTTGQNLI KKVRNLRQRL TARARHRCQT PHLLAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D31 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

thymus: 13 nTPM
bone marrow: 6.9 nTPM
lymph node: 6.6 nTPM
cerebellum: 6.5 nTPM
appendix: 5.7 nTPM
tonsil: 5.7 nTPM

Single-cell type

thyrotrophs: 99 nCPM
cardiomyocytes: 94 nCPM
nk-cells: 94 nCPM
lactotrophs: 68 nCPM
innate lymphoid cells: 66 nCPM
somatotrophs: 56 nCPM

Immune cell

MAIT T-cell: 27 nTPM
NK-cell: 21 nTPM
gdT-cell: 18 nTPM
total PBMC: 16 nTPM
memory CD8 T-cell: 14 nTPM
intermediate monocyte: 13 nTPM

Brain region

cerebellum: 53 nTPM
basal ganglia: 26 nTPM
hippocampal formation: 25 nTPM
white matter: 25 nTPM
cerebral cortex: 24 nTPM
thalamus: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TBC1D31.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 206 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Inherited genitourinary tract anomalies

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0
gnomAD missense Z: 0.91
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cilium assembly

Molecular functions

molecular adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBC1D31 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D31 as an antibody target. Whether an autoantibody or antibody against TBC1D31 could matter depends on whether native TBC1D31 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D31 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBC1D31 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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