Seroatlas · Human Serome Atlas

PRKAR1B

cAMP-dependent protein kinase type I-beta regulatory subunit

Also known as: KAP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P31321
Gene
PRKAR1B
Ensembl
ENSG00000188191
Chromosome
7
Canonical length
381 aa
Protein class
Disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

381 residues, UniProt reviewed canonical sequence.

>P31321|PRKAR1B
     1  MASPPACPSE EDESLKGCEL YVQLHGIQQV LKDCIVHLCI SKPERPMKFL REHFEKLEKE
    61  ENRQILARQK SNSQSDSHDE EVSPTPPNPV VKARRRRGGV SAEVYTEEDA VSYVRKVIPK
   121  DYKTMTALAK AISKNVLFAH LDDNERSDIF DAMFPVTHIA GETVIQQGNE GDNFYVVDQG
   181  EVDVYVNGEW VTNISEGGSF GELALIYGTP RAATVKAKTD LKLWGIDRDS YRRILMGSTL
   241  RKRKMYEEFL SKVSILESLE KWERLTVADA LEPVQFEDGE KIVVQGEPGD DFYIITEGTA
   301  SVLQRRSPNE EYVEVGRLGP SDYFGEIALL LNRPRAATVV ARGPLKCVKL DRPRFERVLG
   361  PCSEILKRNI QRYNSFISLT V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRKAR1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
320 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 320 nTPM
  • hypothalamus: 185 nTPM
  • hippocampal formation: 159 nTPM
  • amygdala: 153 nTPM
  • basal ganglia: 134 nTPM
  • cerebellum: 111 nTPM

Single-cell type

  • platelets: 804 nCPM
  • oocytes: 387 nCPM
  • late spermatids: 228 nCPM
  • other brain neurons: 152 nCPM
  • retinal ganglion cells: 124 nCPM
  • brain excitatory neurons: 121 nCPM

Immune cell

  • naive CD4 T-cell: 13 nTPM
  • naive CD8 T-cell: 13 nTPM
  • total PBMC: 11 nTPM
  • naive B-cell: 9.7 nTPM
  • memory CD4 T-cell: 8.7 nTPM
  • MAIT T-cell: 7.5 nTPM

Brain region

  • cerebral cortex: 549 nTPM
  • white matter: 367 nTPM
  • basal ganglia: 365 nTPM
  • hypothalamus: 352 nTPM
  • pons: 312 nTPM
  • thalamus: 302 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRKAR1B.

Disease | AllUniProt

Conditions PRKAR1B is implicated in, by any mechanism.

  • Marbach-Schaaf neurodevelopmental syndrome (MASNS) MIM:619680

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 164 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Marbach-Schaaf neurodevelopmental syndrome
  • PRKAR1B-related disorder
  • PRKAR1B-related neurodevelopmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0.18
gnomAD missense Z
2.08
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRKAR1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRKAR1B as an antibody target. Whether an autoantibody or antibody against PRKAR1B could matter depends on whether native PRKAR1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRKAR1B is annotated at the cell surface, where native PRKAR1B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PRKAR1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRKAR1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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