PKIG
cAMP-dependent protein kinase inhibitor gamma
Also known as: IPKG_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y2B9
- Gene
- PKIG
- Ensembl
- ENSG00000168734
- Chromosome
- 20
- Canonical length
- 76 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Vesicles,Plasma membrane,Cytosol
OverviewNCBI Gene
This gene encodes a member of the protein kinase inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive cAMP-dependent protein kinase inhibitor, and is a predominant form of inhibitor in various tissues. The encoded protein may be involved in osteogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Canonical amino-acid sequenceUniProt
76 residues, UniProt reviewed canonical sequence.
>Q9Y2B9|PKIG
1 MMEVESSYSD FISCDRTGRR NAVPDIQGDS EAVSVRKLAG DMGELALEGA EGQVEGSAPD
61 KEAGNQPQSS DGTTSSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PKIG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 271 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 271 nTPM
- blood vessel: 211 nTPM
- colon: 184 nTPM
- urinary bladder: 169 nTPM
- lung: 162 nTPM
- kidney: 118 nTPM
Single-cell type
- megakaryocyte-erythroid progenitors: 400 nCPM
- late primary spermatocytes: 367 nCPM
- smooth muscle cells: 335 nCPM
- epididymal efferent duct ciliated cells: 241 nCPM
- respiratory ciliated cells: 237 nCPM
- mast cells: 229 nCPM
Immune cell
- naive B-cell: 379 nTPM
- memory B-cell: 372 nTPM
- plasmacytoid DC: 33 nTPM
- total PBMC: 18 nTPM
- myeloid DC: 9 nTPM
- naive CD8 T-cell: 7.9 nTPM
Brain region
- thalamus: 67 nTPM
- cerebral cortex: 66 nTPM
- hypothalamus: 66 nTPM
- hippocampal formation: 62 nTPM
- medulla oblongata: 61 nTPM
- basal ganglia: 58 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.32
- gnomAD pLI
- 0.51
- gnomAD missense Z
- 0.83
- DepMap mean gene effect
- -0.14
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of protein import into nucleus
- negative regulation of transcription by RNA polymerase II
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PKIG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PKIG as an antibody target. Whether an autoantibody or antibody against PKIG could matter depends on whether native PKIG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PKIG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PKIG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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