Seroatlas · Human Serome Atlas

CRYBG3

Very large A-kinase anchor protein

Also known as: CRBG3_HUMAN, DKFZp667G2110

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68DQ2
Gene: CRYBG3
Ensembl: ENSG00000080200
Chromosome: 3
Canonical length: 2970 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Primary cilium

OverviewNCBI Gene

Enables protein kinase A binding activity. Predicted to be involved in lens development in camera-type eye and visual perception. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2970 residues, UniProt reviewed canonical sequence.

>Q68DQ2|CRYBG3
     1  MSSGRRRGSA PWHSFSRFFA PRSPSRDKEE EEEERPGTSP PPAPGRSAAS VENEPMSTSQ
    61  KKENVLSSEA VKIRQSEDKR NHAEKPVTLP VQEDPKKAYD LSSSTSDTKI GESDRQPKES
   121  FFQFLGNLFN ISGKSSLGEA KQSSFKDDQD KTEKDLQNPS DHHEDGIKRE REIFSGSLRT
   181  QTHPTEEQDS NSSELSDAFS LDTTQDSDQE TTNLLKQIDG KPEKPSVTYA TYRGPRHIGK
   241  YLKQQTGLAT VNTLDRENES SDSSTNRHID PGSEIEAGVL PLLLSASTDS SMKGNLLEGP
   301  LEDSDCSKTS FNKENSLTNN PELQNIASSN NLLNKNAWGS IERNRSSPSS VTNSSYDGES
   361  DSQHHLSCEP VSQTNRNLVC SALLTGSNHR KVPCSPDFQR VTTTENTIKE NSTVMSNRTL
   421  VQREELVEPQ GPAISDFSCS KSDGSDTTEQ ESTNLPSPNK SIRHEHLQLP ESECSDKQTI
   481  DSSSKQAATH TNIIALQRHA VTDTEFVNEG KRLSAQDSQK NVAVREIRRE TESASAGESI
   541  ASSHVKAPED KIESLPKDTD QYFETKAKKL DFRSHDKIPH IRMNKKDLAS LNYISESAVV
   601  ASLGNENAPE LKFELNRSHI SETPLDSESP QQAEVSPDAK TSLSLDCKKL NFSISPPTFV
   661  SGVGMLSKLD IPDLMNEGSP VPIETGNVNI VGISYQPRKC KEENVKNHVE AAGRKSPPPS
   721  FCLEYTSAIF EFKEVLSNSE KCQVLPGSEA SGPHLTGLEL LSFDSGNLSK DCSSILSQDP
   781  NRVELVSSNT KANMSIIEKS DSLSLEAKTA NIVSKAEIDG QNNVLVESHS GRGKTISLSK
   841  VSLSKVEPRN ISQDKMSSFP LKITHVPEKP ILSELTFLEV EQGKRFQSIN HNEIGEKCSD
   901  AGLKENCQAE LSPAASKYED KPEPEVDALG SPPALLKSNI SWILPPIHDE KISRQMAQNC
   961  EAHTCVFHQS LDICGTKKIS GHSEMAELSL TNISPKFQET GSMKVNSPFL DSDSSLEKNS
  1021  SASEDSSFLK VPSVLKLEKK SSSYRKKENI HFLNGGIDSV SSSSSYPEEV SMIVNSHKPQ
  1081  NNLDSIQVTK DLTHEGTSVT NLLYPTTSYL EFETSVSIGT EVTPFQEHFG IYTGKISIDF
  1141  PTAAQFDNLV EAETGAVAGP AASVNSSGQQ CSEASAEHIE ARRRAHDQLL DLKSSLLKKA
  1201  DTLIGEIFNS VREELKFKHT VSTCQEHIAI EGIMNLGTLK EDISEKNPSE VTLTEIQQTE
  1261  GLEEQGMENM SEVKEKPCVS PTVGEKNLLV DPNSMNVSCL LEDKARELVN EIIYVAQEKL
  1321  RNDTFEDTED TWDSELQANT SKILNSDSVK PHDVVREFLV SEQPVNQSTQ ISENKVLNEF
  1381  FSLSNLASGT ESIKGGEIVL YQKSLFSGNG SGLSDSINLQ ESDTVLLAED MSHKRLDDRV
  1441  KTHLFRSEDC NETMEIENVD NNKTETEDRR TLVLNFKWPP LVNDDIHAPG TSKSSLSDSL
  1501  VCISEKNLPG HSKNTPLAMS DVGKVHKKDN EINIGKIELI PSMLETGKTN KKDAELNILK
  1561  YEAVPPMIEM GRIHKMDAEL NVTKTEPKAN VFKMGEVYQM DAESCIEKTE GSAVILGMEK
  1621  AYKMKDTEGD IGKIEVIPMM PEVKNIHQKD AEGDIVKTEM TPVTVDMENI YQTHAEGDIG
  1681  KTGTIALSEV ENIHQKGGEG ISEKAEVIPV TLAMENTYQK DAEGDIGKAE VMPVRLEMEN
  1741  TYPKDTERDG GKTEVMPLAL EVVNTYQKNA KGFTGNTEGS VLKMEATYRK TAEEVIKNTE
  1801  IVPCVLKVKE AHETAPAPLE MEKACKRDVK ETIGATVSTP SVIEMEKISP EDRGENIGKH
  1861  KVLPAVVDIE KIHGTGLELT TKQGEAMLPA FESKTPQEYA EGSVEETKEE PTEIKEGLIA
  1921  HENRLPTYFR GYESPTLSKD YEGYPAPAMP DFQPGDTTVR LDKRMSLTAI YDKRRETDYS
  1981  DKGYNLAFVS QDEQENSSFT ILYEEPLQEE DKYASAEARQ TQSVLFHDTS ADSMPVLACE
  2041  RSESRTDLVH HFEKGTKLGE TFDSDSSEMF LSVEAKRYKI YPLALSPIYE DDSSQEDILS
  2101  SEVSPGHHGP RKSRDSENQS SSVLSLLQSV SERLKMNFDE DDREAADEEE EEEEAAVLHK
  2161  GDLRAGSGER VTFQLPDPSI TFYPDDQESV GISKNSYVMP NEPTTSNLQV GLWPEKTSFL
  2221  QKSDLTSKLH SSLKSAYHQY LQTSQSHSSE KGARFGGIFQ EPVSKYFRVQ DSPGRLSPFI
  2281  ENVDKQTLRC NPRPGKMVIY DLHESTYKQE VYCNIPDATS WSFPNGVLIK VVRGCWILYE
  2341  KPHFRGQKCV LEEGEKVLNR DWILQNRRHP QRNFILGSLK RVLKDCSIPE IELFPQSDPA
  2401  CCPVYIQRAV PNLEELNISK SVSFTVKSGV WLAYPDINFK GQATVLEEDH GLFEISTAEM
  2461  KSLHPLQMGG LKVEMPMNLK VIIYEKPHFH GQAKEFSEHI DSVPNFLKNN GDFHRIGSIR
  2521  VIGGVWVAYE KEHFKGQQFL LEEGDFEDSN ACGALSSPIL SFRYLQANFI ESSVTLFESD
  2581  LESGKFIDIT NQEISDLEEI GFGSKTRSIH VKSGVWVAYQ QKFFCGEQYI LEKGKYKCFF
  2641  DWGGSNNIIM SIRPIQLEPL GINEPPHLLK AFSKPGFQGE CIDFTEETSD LTSLMPCSFK
  2701  VLRGCWLLYY QEDMFVNHCV LEEGLYADLT SCGCPASKVK SLKPIDYVFE EPSISLFALE
  2761  HCEGRELHLE EAVNSVLNKD LHFYTQSVWV KSGLWIAYEG SNFLGRQILL RPNEIPNWTA
  2821  FSRWKTIGSL RPMKQPAVYI RIKNRAQGEY LTVTGSLADT RATSVCISPY SGKNTQIWYY
  2881  CRGLFKSKAS DTCLDVIGGR DTPGAKVALW TEHGQFRQKW RLNKNGTISS YLSDQLVLDV
  2941  KGGNYCDKTH VIVNQPLEGE ETQKWDIEIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRYBG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 25 nTPM
testis: 13 nTPM
skin: 12 nTPM
placenta: 10 nTPM
adipose tissue: 9.9 nTPM
tongue: 9.2 nTPM

Single-cell type

retinal bipolar cells: 269 nCPM
renal collecting duct intercalated cells: 263 nCPM
late spermatids: 182 nCPM
late primary spermatocytes: 180 nCPM
ocular epithelial cells: 177 nCPM
adipocytes: 175 nCPM

Immune cell

plasmacytoid DC: 3.6 nTPM
basophil: 1.5 nTPM
classical monocyte: 1.4 nTPM
myeloid DC: 1.4 nTPM
non-classical monocyte: 1 nTPM
intermediate monocyte: 0.9 nTPM

Brain region

white matter: 40 nTPM
medulla oblongata: 39 nTPM
basal ganglia: 31 nTPM
spinal cord: 30 nTPM
pons: 28 nTPM
hypothalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0
gnomAD missense Z: 0.47

OntologyGO

Biological processes

Molecular functions

Cellular components

protein-containing complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CRYBG3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PRKACA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRYBG3 as an antibody target. Whether an autoantibody or antibody against CRYBG3 could matter depends on whether native CRYBG3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRYBG3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CRYBG3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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