Seroatlas · Human Serome Atlas

PKIA

cAMP-dependent protein kinase inhibitor alpha

Also known as: IPKA_HUMAN, PRKACN1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61925
Gene: PKIA
Ensembl: ENSG00000171033
Chromosome: 8
Canonical length: 76 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

76 residues, UniProt reviewed canonical sequence.

>P61925|PKIA
     1  MTDVETTYAD FIASGRTGRR NAIHDILVSS ASGNSNELAL KLAGLDINKT EGEEDAQRSS
    61  TEQSGEAQGE AAKSES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PKIA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 1,088 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 1,088 nTPM
tongue: 890 nTPM
heart muscle: 174 nTPM
parathyroid gland: 102 nTPM
basal ganglia: 63 nTPM
cerebral cortex: 61 nTPM

Single-cell type

myonuclei: 269 nCPM
lactotrophs: 203 nCPM
somatotrophs: 189 nCPM
brain inhibitory neurons: 175 nCPM
retinal amacrine cells: 165 nCPM
thymic myoid cells: 158 nCPM

Immune cell

T-reg: 22 nTPM
memory CD4 T-cell: 9.2 nTPM
naive CD4 T-cell: 7.7 nTPM
naive CD8 T-cell: 4.6 nTPM
total PBMC: 2.5 nTPM
memory B-cell: 2.3 nTPM

Brain region

cerebral cortex: 84 nTPM
basal ganglia: 83 nTPM
hypothalamus: 81 nTPM
hippocampal formation: 72 nTPM
cerebellum: 67 nTPM
amygdala: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0.14
gnomAD missense Z: 0.79
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of cAMP/PKA signal transduction
negative regulation of protein import into nucleus
negative regulation of transcription by RNA polymerase II
regulation of G2/M transition of mitotic cell cycle
negative regulation of cAMP-dependent protein kinase activity

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PKIA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PRKACA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PKIA as an antibody target. Whether an autoantibody or antibody against PKIA could matter depends on whether native PKIA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PKIA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PKIA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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