Seroatlas · Human Serome Atlas

PDE7A

High affinity 3',5'-cyclic-AMP phosphodiesterase 7A

Also known as: HCP1, PDE7A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13946
Gene: PDE7A
Ensembl: ENSG00000205268
Chromosome: 8
Canonical length: 482 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]

Canonical amino-acid sequenceUniProt

482 residues, UniProt reviewed canonical sequence.

>Q13946|PDE7A
     1  MEVCYQLPVL PLDRPVPQHV LSRRGAISFS SSSALFGCPN PRQLSQRRGA ISYDSSDQTA
    61  LYIRMLGDVR VRSRAGFESE RRGSHPYIDF RIFHSQSEIE VSVSARNIRR LLSFQRYLRS
   121  SRFFRGTAVS NSLNILDDDY NGQAKCMLEK VGNWNFDIFL FDRLTNGNSL VSLTFHLFSL
   181  HGLIEYFHLD MMKLRRFLVM IQEDYHSQNP YHNAVHAADV TQAMHCYLKE PKLANSVTPW
   241  DILLSLIAAA THDLDHPGVN QPFLIKTNHY LATLYKNTSV LENHHWRSAV GLLRESGLFS
   301  HLPLESRQQM ETQIGALILA TDISRQNEYL SLFRSHLDRG DLCLEDTRHR HLVLQMALKC
   361  ADICNPCRTW ELSKQWSEKV TEEFFHQGDI EKKYHLGVSP LCDRHTESIA NIQIGFMTYL
   421  VEPLFTEWAR FSNTRLSQTM LGHVGLNKAS WKGLQREQSS SEDTDAAFEL NSQLLPQENR
   481  LS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDE7A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 101 nTPM

Expression across tissuesHPA

Tissue

thymus: 101 nTPM
tongue: 71 nTPM
skeletal muscle: 58 nTPM
lymph node: 55 nTPM
heart muscle: 41 nTPM
tonsil: 40 nTPM

Single-cell type

thymocytes: 986 nCPM
myonuclei: 924 nCPM
b-cells: 701 nCPM
proximal tubule cells: 647 nCPM
corticotrophs: 612 nCPM
t-cells: 575 nCPM

Immune cell

naive CD4 T-cell: 12 nTPM
naive CD8 T-cell: 9.3 nTPM
naive B-cell: 7.5 nTPM
memory B-cell: 6.5 nTPM
eosinophil: 5.5 nTPM
MAIT T-cell: 5.5 nTPM

Brain region

white matter: 29 nTPM
thalamus: 25 nTPM
cerebellum: 25 nTPM
basal ganglia: 23 nTPM
choroid plexus: 23 nTPM
cerebral cortex: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0
gnomAD missense Z: 1.72
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDE7A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDE7A as an antibody target. Whether an autoantibody or antibody against PDE7A could matter depends on whether native PDE7A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDE7A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDE7A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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