Seroatlas · Human Serome Atlas

TSC22D4

TSC22 domain family protein 4

Also known as: T22D4_HUMAN, THG-1, TILZ2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3Q8
Gene: TSC22D4
Ensembl: ENSG00000166925
Chromosome: 7
Canonical length: 395 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

TSC22D4 is a member of the TSC22 domain family of leucine zipper transcriptional regulators (see TSC22D3; MIM 300506) (Kester et al., 1999 [PubMed 10488076]; Fiorenza et al., 2001 [PubMed 11707329]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

395 residues, UniProt reviewed canonical sequence.

>Q9Y3Q8|TSC22D4
     1  MSGGKKKSSF QITSVTTDYE GPGSPGASDP PTPQPPTGPP PRLPNGEPSP DPGGKGTPRN
    61  GSPPPGAPSS RFRVVKLPHG LGEPYRRGRW TCVDVYERDL EPHSFGGLLE GIRGASGGAG
   121  GRSLDSRLEL ASLGLGAPTP PSGLSQGPTS WLRPPPTSPG PQARSFTGGL GQLVVPSKAK
   181  AEKPPLSASS PQQRPPEPET GESAGTSRAA TPLPSLRVEA EAGGSGARTP PLSRRKAVDM
   241  RLRMELGAPE EMGQVPPLDS RPSSPALYFT HDASLVHKSP DPFGAVAAQK FSLAHSMLAI
   301  SGHLDSDDDS GSGSLVGIDN KIEQAMDLVK SHLMFAVREE VEVLKEQIRE LAERNAALEQ
   361  ENGLLRALAS PEQLAQLPSS GVPRLGPPAP NGPSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSC22D4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 851 nTPM

Expression across tissuesHPA

Tissue

midbrain: 851 nTPM
spinal cord: 767 nTPM
basal ganglia: 692 nTPM
amygdala: 632 nTPM
hippocampal formation: 557 nTPM
hypothalamus: 449 nTPM

Single-cell type

müller glia: 441 nCPM
esophageal apical cells: 389 nCPM
retinal pigment epithelial cells: 290 nCPM
bergmann glia: 246 nCPM
oligodendrocytes: 239 nCPM
schwann cells: 227 nCPM

Immune cell

neutrophil: 56 nTPM
eosinophil: 30 nTPM
T-reg: 25 nTPM
non-classical monocyte: 21 nTPM
intermediate monocyte: 20 nTPM
gdT-cell: 19 nTPM

Brain region

basal ganglia: 858 nTPM
midbrain: 785 nTPM
white matter: 766 nTPM
thalamus: 756 nTPM
medulla oblongata: 712 nTPM
cerebellum: 707 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.96
gnomAD missense Z: 1
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSC22D4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSC22D4 as an antibody target. Whether an autoantibody or antibody against TSC22D4 could matter depends on whether native TSC22D4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSC22D4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSC22D4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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