Seroatlas · Human Serome Atlas

MSL1

Male-specific lethal 1 homolog

Also known as: DKFZp686P24239, hMSL1, MSL-1, MSL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68DK7
Gene: MSL1
Ensembl: ENSG00000188895
Chromosome: 17
Canonical length: 614 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables protein-macromolecule adaptor activity. Involved in positive regulation of DNA-templated transcription. Located in nucleoplasm. Part of MSL complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

614 residues, UniProt reviewed canonical sequence.

>Q68DK7|MSL1
     1  MTMRSAVFKA AAAPAGGNPE QRLDYERAAA LGGPEDEPGA AEAHFLPRHR KLKEPGPPLA
    61  SSQGGSPAPS PAGCGGKGRG LLLPAGAAPG QQEESWGGSV PLPCPPPATK QAGIGGEPAA
   121  AGAGCSPRPK YQAVLPIQTG SLVAAAKEPT PWAGDKGGAA SPAATASDPA GPPPLPLPGP
   181  PPLAPTATAG TLAASEGRWK SMRKSPLGGG GGSGASSQAA CLKQILLLQL DLIEQQQQQL
   241  QAKEKEIEEL KSERDTLLAR IERMERRMQL VKKDNEKERH KLFQGYETEE REETELSEKI
   301  KLECQPELSE TSQTLPPKPF SCGRSGKGHK RKSPFGSTER KTPVKKLAPE FSKVKTKTPK
   361  HSPIKEEPCG SLSETVCKRE LRSQETPEKP RSSVDTPPRL STPQKGPSTH PKEKAFSSEI
   421  EDLPYLSTTE MYLCRWHQPP PSPLPLRESS PKKEETVARC LMPSSVAGET SVLAVPSWRD
   481  HSVEPLRDPN PSDLLENLDD SVFSKRHAKL ELDEKRRKRW DIQRIREQRI LQRLQLRMYK
   541  KKGIQESEPE VTSFFPEPDD VESLMITPFL PVVAFGRPLP KLTPQNFELP WLDERSRCRL
   601  EIQKKQTPHR TCRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 84 nTPM

Expression across tissuesHPA

Tissue

spleen: 84 nTPM
cervix: 79 nTPM
fallopian tube: 78 nTPM
thyroid gland: 77 nTPM
endometrium: 76 nTPM
pituitary gland: 75 nTPM

Single-cell type

neutrophils: 605 nCPM
neutrophil progenitors: 139 nCPM
early primary spermatocytes: 81 nCPM
bergmann glia: 74 nCPM
esophageal apical cells: 69 nCPM
leydig cells: 68 nCPM

Immune cell

neutrophil: 8.7 nTPM
gdT-cell: 1.7 nTPM
plasmacytoid DC: 1.4 nTPM
memory CD8 T-cell: 1.3 nTPM
memory B-cell: 1.1 nTPM
classical monocyte: 1 nTPM

Brain region

cerebral cortex: 94 nTPM
amygdala: 91 nTPM
basal ganglia: 88 nTPM
hippocampal formation: 82 nTPM
thalamus: 78 nTPM
hypothalamus: 75 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.15
gnomAD pLI: 1
gnomAD missense Z: 1.77
DepMap mean gene effect: -0.39
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein-macromolecule adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

PEHE domain
PEHE domain
Protein male-specific lethal-1
Protein male-specific lethal-1, dimerisation domain
Dimerisation domain of Male-specific-Lethal 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MSL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MSL1 as an antibody target. Whether an autoantibody or antibody against MSL1 could matter depends on whether native MSL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MSL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MSL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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