Seroatlas · Human Serome Atlas

FBF1

Fas-binding factor 1

Also known as: ALB, FBF-1, FBF1_HUMAN, FLJ00103, KIAA1863

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TES7
Gene
FBF1
Ensembl
ENSG00000188878
Chromosome
17
Canonical length
1133 aa
Protein class
Predicted intracellular proteins
Subcellular location
Primary cilium,Centrosome,Basal body

OverviewNCBI Gene

Involved in apical junction assembly and establishment of epithelial cell polarity. Acts upstream of or within cilium assembly. Located in apical junction complex and cytoskeleton. Part of ciliary transition fiber. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1133 residues, UniProt reviewed canonical sequence.

>Q8TES7|FBF1
     1  MAPKTKKGCK VTLPEKPVKL ASHTRDTTGV SQMFPSSKAR TKSLLGDDVF STMAGLEEAD
    61  AEVSGISEAD PQALLQAMKD LDGMDADILG LKKSNSAPSK KAAKDPGKGE LPNHPKPAGG
   121  AIPTKKSLPS PSSSGHQNRR FSSEDLEDPL RGLLSYDEGG ITKQPPVTQS KTASDKSPST
   181  VRDQGPSIPL TPGDTPIRKK EELLFDDGDD IMATLGFGDS PKAEKRQIGD QEGPRPARST
   241  LDELLGRGMA TKLLARPGTG EHREFKLDKK YQRPQDSEDM WGDEDFTFGA YQPTVVSSEG
   301  RQSRRQSVSR FFADSGADPK GEPGSKQSPP MASSPIQPRK GGADWLGLKD EDLDLFPASP
   361  TREAHRESSV PVTPSVPPPA SQHSTPAGLP PSRAKPPTEG AGSPAKASQA SKLRASKEEK
   421  EDWLSHALSR KKSQGLAREQ HAGTSEGLHL AGTAGHPPSG SQPLTSTQGL EHAAAGGSSG
   481  TTARERPCVR PGVSGSPVTQ NHAASALPTG SPKRGTAPGD LSATEPATCF PSTQKPTEPS
   541  VPVQPLLPES LARSLLPSTE YQKQLLAAQV QLQCSPAELQ AELLHSQARL AELEAQVRKL
   601  ELERAQHELL LGSLQQQHQA DLELIESAHR SRIKVLETSY QQREERLRRE NEELSARYLS
   661  QCQEAEQARA ELTAQHQRRL AAIAQEKDQE MERLRELQRA SILDMRRDHE EQLQRLKLLK
   721  DREVDAATSA TSHTRSLNSI IHQMEKFSSS LHELSSRVEA SHLTTSQERE LGIRQRDEQL
   781  RALQERLGQQ QRDMEEERSR QQEVIGKMEA RLNEQSRLLE QERWRVTAEQ SKAESMQRAL
   841  EEQRKVTAQQ MAMERAELER AKSALLEEQK SVMLKCGEER RRLAAEWAEF SAQQKLSKER
   901  AEREAERALQ VDTQREGTLI SLAKQAELKI RASELRAEEK QLAAERAALE QERQELRLEK
   961  ERINATALRV KLRAEEVESM SKVASEKYEE GERALREAQQ VQAEQQARLQ AVQQQQERLR
  1021  KQEQHMHQEH LSLAQQRLQL DRARQDLPSS LVGLFPRAQG PAASSQSALM PPAPTTRWCS
  1081  QPPTGLDPSP LHLHARLALL RHMAEQDRDF LENEQFFLET LKKGSYNLTS HSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • testis: 30 nTPM
  • thyroid gland: 18 nTPM
  • pituitary gland: 12 nTPM
  • skin: 12 nTPM
  • prostate: 9.3 nTPM
  • spinal cord: 8.7 nTPM

Single-cell type

  • early primary spermatocytes: 52 nCPM
  • retinal ganglion cells: 35 nCPM
  • ependymal cells: 27 nCPM
  • cytotrophoblasts: 23 nCPM
  • respiratory ciliated cells: 23 nCPM
  • differentiating spermatogonia: 23 nCPM

Immune cell

  • T-reg: 0.5 nTPM
  • memory CD8 T-cell: 0.4 nTPM
  • plasmacytoid DC: 0.4 nTPM
  • gdT-cell: 0.3 nTPM
  • intermediate monocyte: 0.3 nTPM
  • naive CD4 T-cell: 0.3 nTPM

Brain region

  • basal ganglia: 19 nTPM
  • thalamus: 18 nTPM
  • white matter: 17 nTPM
  • medulla oblongata: 17 nTPM
  • midbrain: 17 nTPM
  • cerebral cortex: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0
gnomAD missense Z
1.06
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Fas-binding factor 1
  • Fas-binding factor 1, C-terminal
  • Fas-binding factor 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBF1 as an antibody target. Whether an autoantibody or antibody against FBF1 could matter depends on whether native FBF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBF1 is annotated at the cell surface, where native FBF1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FBF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FBF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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