Seroatlas · Human Serome Atlas

SAPCD2

Suppressor APC domain-containing protein 2

Also known as: C9orf140, p42.3, SAPC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86UD0
Gene
SAPCD2
Ensembl
ENSG00000186193
Chromosome
9
Canonical length
394 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Involved in negative regulation of protein localization to cell cortex and positive regulation of cell population proliferation. Located in several cellular components, including apical cortex; apical junction complex; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

394 residues, UniProt reviewed canonical sequence.

>Q86UD0|SAPCD2
     1  MAGAAMAERG RVPPPAPAPS TEGLPRAFLQ SLRTLFDILD DRRRGCVHLR EIESRWQGTD
    61  ARELPRGVLE GLRQVAPASG YLTFERFVAG LRTSLLSADG GPRDPTRAPA RPGDQPPPPP
   121  QRLVFAPADE PRTVLERKPL PLGVRAPLAG PSAAARSPEQ LCAPAEAAPC PAEPERSQSA
   181  ALEPSSSADA GAVACRALEA DSGDARRAPR ARGERRRHTI ASGVDCGLLK QMKELEQEKE
   241  VLLQGLEMMA RGRDWYQQQL QRVQERQRRL GQSRASADFG AAGSPRPLGR LLPKVQEVAR
   301  CLGELLAAAC ASRALPPSSS GPPCPALTST SPPVWQQQTI LMLKEQNRLL TQEVTEKSER
   361  ITQLEQEKSA LIKQLFEARA LSQQDGGPLD STFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAPCD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 13 nTPM
  • hippocampal formation: 11 nTPM
  • cerebral cortex: 8.5 nTPM
  • hypothalamus: 8.4 nTPM
  • midbrain: 8.4 nTPM
  • esophagus: 8.2 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 46 nCPM
  • monocyte progenitors: 41 nCPM
  • enteric transient amplifying cells: 25 nCPM
  • gastric progenitor cells: 21 nCPM
  • paneth cells: 19 nCPM
  • esophageal basal cells: 13 nCPM

Immune cell

  • classical monocyte: 0.2 nTPM
  • myeloid DC: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • medulla oblongata: 14 nTPM
  • white matter: 13 nTPM
  • amygdala: 13 nTPM
  • midbrain: 13 nTPM
  • thalamus: 13 nTPM
  • pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
gnomAD missense Z
0.83
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SAPCD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAPCD2 as an antibody target. Whether an autoantibody or antibody against SAPCD2 could matter depends on whether native SAPCD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAPCD2 is annotated at the cell surface, where native SAPCD2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SAPCD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SAPCD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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