Seroatlas · Human Serome Atlas

FRMD4B

FERM domain-containing protein 4B

Also known as: FRM4B_HUMAN, GRSP1, KIAA1013

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2L6
Gene
FRMD4B
Ensembl
ENSG00000114541
Chromosome
3
Canonical length
1034 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Centriolar satellite

OverviewNCBI Gene

This gene encodes a GRP1-binding protein which contains a FERM protein interaction domain as well as two coiled coil domains. This protein may play a role as a scaffolding protein. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

1034 residues, UniProt reviewed canonical sequence.

>Q9Y2L6|FRMD4B
     1  MASVFMCGVE DLLFSGSRFV WNLTVSTLRR WYTERLRACH QVLRTWCGLQ DVYQMTEGRH
    61  CQVHLLDDRR LELLVQPKLL ARELLDLVAS HFNLKEKEYF GITFIDDTGQ QNWLQLDHRV
   121  LDHDLPKKPG PTILHFAVRF YIESISFLKD KTTVELFFLN AKACVHKGQI EVESETIFKL
   181  AAFILQEAKG DYTSDENARK DLKTLPAFPT KTLQEHPSLA YCEDRVIEHY LKIKGLTRGQ
   241  AVVQYMKIVE ALPTYGVHYY AVKDKQGLPW WLGISYKGIG QYDIQDKVKP RKLFQWKQLE
   301  NLYFREKKFA VEVHDPRRIS VSRRTFGQSG LFVQTWYANS SLIKSIWVMA ISQHQFYLDR
   361  KQSKAKIPSA RSLDEIAMDL TETGTQRASK LVTLETKSQF IMASNGSLIS SGSQDSEVSE
   421  EQKREKILEL KKKEKLLQEK LLKKVEELKK ICLREAELTG KMPKEYPLNI GEKPPQVRRR
   481  VGTAFKLDDN LLPSEEDPAL QELESNFLIQ QKLVEAAKKL ANEPDLCKTV KKKRKQDYTD
   541  AMKKLQEIEN AINEYRIRCG KKPSQKATVL PEDIIPSESS SLSDTTTYDD PSDAFTFPGQ
   601  RSSSVPHSPR ILPPKSLGIE RIHFRKSSIN EQFVDTRQSR EMLSTHSSPY KTLERRPQGG
   661  RSMPTTPVLT RNAYSSSHLE PESSSQHCRQ RSGSLESQSH LLSEMDSDKP FFSLSKSQRS
   721  SSTEILDDGS SYTSQSSTEY YCVTPVTGPY YTTQTLDTRT RGRRRSKKQN VSTSNSGSMP
   781  NLAQKDSLRN GVYSKSQEPP SSSYYIAGYT PYAECDFYYS GGYVYENDTE GQYSVNPSYR
   841  SSAHYGYERQ RDYSRSFHED EVDRVPHNPY ATLRLPRKAA AKSEHITKNI HKALVAEHLR
   901  GWYQRASGQK DQGHSPQTSF DSDRGSQRCL GFAGLQVPCS PSSRASSYSS VSSTNASGNW
   961  RTQLTIGLSD YETPAHSSYT SCYGNVYNPL PSPSRQYTEI SQLDGTDGNQ LEDNLESSEQ
  1021  RLFWHEDSKP GTLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRMD4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 35 nTPM
  • liver: 32 nTPM
  • spleen: 30 nTPM
  • thyroid gland: 25 nTPM
  • esophagus: 25 nTPM
  • placenta: 24 nTPM

Single-cell type

  • oligodendrocytes: 1,580 nCPM
  • kupffer cells: 1,370 nCPM
  • cone photoreceptor cells: 1,236 nCPM
  • macrophages: 951 nCPM
  • esophageal apical cells: 825 nCPM
  • rod photoreceptor cells: 768 nCPM

Immune cell

  • classical monocyte: 28 nTPM
  • basophil: 18 nTPM
  • myeloid DC: 17 nTPM
  • plasmacytoid DC: 17 nTPM
  • T-reg: 15 nTPM
  • intermediate monocyte: 14 nTPM

Brain region

  • white matter: 186 nTPM
  • basal ganglia: 114 nTPM
  • thalamus: 106 nTPM
  • medulla oblongata: 102 nTPM
  • midbrain: 96 nTPM
  • pons: 91 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.45
gnomAD missense Z
-0.04
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FRMD4B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FRMD4B as an antibody target. Whether an autoantibody or antibody against FRMD4B could matter depends on whether native FRMD4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FRMD4B is annotated at the cell surface, where native FRMD4B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FRMD4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FRMD4B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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