Seroatlas · Human Serome Atlas

LRRFIP1

Leucine-rich repeat flightless-interacting protein 1

Also known as: FLAP-1, FLIIAP1, GCF-2, GCF2, HUFI-1, LRRF1_HUMAN, TRIP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q32MZ4
Gene: LRRFIP1
Ensembl: ENSG00000124831
Chromosome: 2
Canonical length: 808 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

808 residues, UniProt reviewed canonical sequence.

>Q32MZ4|LRRFIP1
     1  MTSPAAAQSR EIDCLSPEAQ KLAEARLAAK RAARAEAREI RMKELERQQK EEDSERYSRR
    61  SRRNTSASDE DERMSVGSRG SLRVEERPEK DFTEKGSRNM PGLSAATLAS LGGTSSRRGS
   121  GDTSISIDTE ASIREIKELN ELKDQIQDVE GKYMQGLKEM KDSLAEVEEK YKKAMVSNAQ
   181  LDNEKTNFMY QVDTLKDMLL ELEEQLAESR RQYEEKNKEF EREKHAHSIL QFQFAEVKEA
   241  LKQREEMLEK HGIILNSEIA TNGETSDTLN NVGYQGPTKM TKEELNALKS TGDGTLGRAS
   301  EVEVKNEIVA NVGKREILHN TEKEQHTEDT VKDCVDIEVF PAGENTEDQK SSEDTAPFLG
   361  TLAGATYEEQ VQSQILESSS LPENTVQVES NEVMGAPDDR TRTPLEPSNC WSDLDGGNHT
   421  ENVGEAAVTQ VEEQAGTVAS CPLGHSDDTV YHDDKCMVEV PQELETSTGH SLEKEFTNQE
   481  AAEPKEVPAH STEVGRDHNE EEGEETGLRD EKPIKTEVPG SPAGTEGNCQ EATGPSTVDT
   541  QNEPLDMKEP DEEKSDQQGE ALDSSQKKTK NKKKKNKKKK SPVPVETLKD VKKELTYQNT
   601  DLSEIKEEEQ VKSTDRKSAV EAQNEVTENP KQKIAAESSE NVDCPENPKI KLDGKLDQEG
   661  DDVQTAAEEV LADGDTLDFE DDTVQSSGPR AGGEELDEGV AKDNAKIDGA TQSSPAEPKS
   721  EDADRCTLPE HESPSQDISD ACEAESTERC EMSEHPSQTV RKALDSNSLE NDDLSAPGRE
   781  PGHFNPESRE DTRGGNEKGK SKEDCTMS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRFIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 102 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 102 nTPM
blood vessel: 87 nTPM
bone marrow: 82 nTPM
urinary bladder: 69 nTPM
smooth muscle: 66 nTPM
heart muscle: 62 nTPM

Single-cell type

neutrophils: 1,923 nCPM
urothelial cells: 1,339 nCPM
neutrophil progenitors: 1,235 nCPM
endometrial luminal cells: 1,224 nCPM
esophageal apical cells: 1,163 nCPM
monocyte progenitors: 1,117 nCPM

Immune cell

neutrophil: 329 nTPM
eosinophil: 250 nTPM
non-classical monocyte: 170 nTPM
classical monocyte: 105 nTPM
intermediate monocyte: 98 nTPM
memory CD4 T-cell: 89 nTPM

Brain region

choroid plexus: 62 nTPM
hippocampal formation: 41 nTPM
hypothalamus: 40 nTPM
amygdala: 40 nTPM
cerebral cortex: 40 nTPM
thalamus: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0.02
gnomAD missense Z: -0.35
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRFIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRFIP1 as an antibody target. Whether an autoantibody or antibody against LRRFIP1 could matter depends on whether native LRRFIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRFIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRFIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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