Seroatlas · Human Serome Atlas

STAP2

Signal-transducing adaptor protein 2

Also known as: BKS, STAP-2, STAP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UGK3
Gene
STAP2
Ensembl
ENSG00000178078
Chromosome
19
Canonical length
403 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

403 residues, UniProt reviewed canonical sequence.

>Q9UGK3|STAP2
     1  MASALRPPRV PKPKGVLPSH YYESFLEKKG PCDRDYKKFW AGLQGLTIYF YNSNRDFQHV
    61  EKLNLGAFEK LTDEIPWGSS RDPGTHFSLI LRDQEIKFKV ETLECREMWK GFILTVVELR
   121  VPTDLTLLPG HLYMMSEVLA KEEARRALET PSCFLKVSRL EAQLLLERYP ECGNLLLRPS
   181  GDGADGVSVT TRQMHNGTHV VRHYKVKREG PKYVIDVEQP FSCTSLDAVV NYFVSHTKKA
   241  LVPFLLDEDY EKVLGYVEAD KENGENVWVA PSAPGPGPAP CTGGPKPLSP ASSQDKLPPL
   301  PPLPNQEENY VTPIGDGPAV DYENQDVASS SWPVILKPKK LPKPPAKLPK PPVGPKPEPK
   361  VFNGGLGRKL PVSSAQPLFP TAGLADMTAE LQKKLEKRRA LEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
90 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 90 nTPM
  • duodenum: 73 nTPM
  • skin: 72 nTPM
  • colon: 68 nTPM
  • small intestine: 68 nTPM
  • rectum: 56 nTPM

Single-cell type

  • enterocytes: 425 nCPM
  • esophageal apical cells: 379 nCPM
  • colonocytes: 356 nCPM
  • esophageal suprabasal cells: 290 nCPM
  • enteric transient amplifying cells: 178 nCPM
  • esophageal basal cells: 160 nCPM

Immune cell

  • NK-cell: 8 nTPM
  • T-reg: 2.5 nTPM
  • MAIT T-cell: 2.3 nTPM
  • naive CD4 T-cell: 2.3 nTPM
  • plasmacytoid DC: 2.2 nTPM
  • naive CD8 T-cell: 1.4 nTPM

Brain region

  • cerebellum: 4.6 nTPM
  • choroid plexus: 4.4 nTPM
  • cerebral cortex: 3.4 nTPM
  • basal ganglia: 2.6 nTPM
  • pons: 2.5 nTPM
  • amygdala: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.43
gnomAD pLI
0
gnomAD missense Z
0.6
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STAP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STAP2 as an antibody target. Whether an autoantibody or antibody against STAP2 could matter depends on whether native STAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STAP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STAP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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