Seroatlas · Human Serome Atlas

IL1RL1

Interleukin-1 receptor-like 1

Also known as: DER4, FIT-1, IL33R, ILRL1_HUMAN, ST2, ST2L, ST2V, T1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q01638
Gene
IL1RL1
Ensembl
ENSG00000115602
Chromosome
2
Canonical length
556 aa
Protein class
Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Plasma membrane,Focal adhesion sites,Cytosol
Secretome location
Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

556 residues, UniProt reviewed canonical sequence.

>Q01638|IL1RL1
     1  MGFWILAILT ILMYSTAAKF SKQSWGLENE ALIVRCPRQG KPSYTVDWYY SQTNKSIPTQ
    61  ERNRVFASGQ LLKFLPAAVA DSGIYTCIVR SPTFNRTGYA NVTIYKKQSD CNVPDYLMYS
   121  TVSGSEKNSK IYCPTIDLYN WTAPLEWFKN CQALQGSRYR AHKSFLVIDN VMTEDAGDYT
   181  CKFIHNENGA NYSVTATRSF TVKDEQGFSL FPVIGAPAQN EIKEVEIGKN ANLTCSACFG
   241  KGTQFLAAVL WQLNGTKITD FGEPRIQQEE GQNQSFSNGL ACLDMVLRIA DVKEEDLLLQ
   301  YDCLALNLHG LRRHTVRLSR KNPIDHHSIY CIIAVCSVFL MLINVLVIIL KMFWIEATLL
   361  WRDIAKPYKT RNDGKLYDAY VVYPRNYKSS TDGASRVEHF VHQILPDVLE NKCGYTLCIY
   421  GRDMLPGEDV VTAVETNIRK SRRHIFILTP QITHNKEFAY EQEVALHCAL IQNDAKVILI
   481  EMEALSELDM LQAEALQDSL QHLMKVQGTI KWREDHIANK RSLNSKFWKH VRYQMPVPSK
   541  IPRKASSLTP LAAQKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL1RL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
188 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 188 nTPM
  • lung: 159 nTPM
  • kidney: 117 nTPM
  • choroid plexus: 58 nTPM
  • adrenal gland: 32 nTPM
  • stomach: 24 nTPM

Single-cell type

  • mast cells: 329 nCPM
  • epididymal basal cells: 120 nCPM
  • pericytes: 38 nCPM
  • hepatic stellate cells: 26 nCPM
  • neutrophils: 20 nCPM
  • vascular endothelial cells: 17 nCPM

Immune cell

  • basophil: 38 nTPM
  • eosinophil: 29 nTPM
  • NK-cell: 0.5 nTPM
  • MAIT T-cell: 0.4 nTPM
  • total PBMC: 0.1 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • choroid plexus: 15 nTPM
  • basal ganglia: 11 nTPM
  • thalamus: 11 nTPM
  • white matter: 8.8 nTPM
  • cerebral cortex: 8.2 nTPM
  • spinal cord: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.17
gnomAD pLI
0
gnomAD missense Z
-1.19
DepMap mean gene effect
0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IL1RL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL1RL1 as an antibody target. Whether an autoantibody or antibody against IL1RL1 could matter depends on whether native IL1RL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL1RL1 is annotated at the cell surface, where native IL1RL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IL1RL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IL1RL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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