Seroatlas · Human Serome Atlas

LRRFIP2

Leucine-rich repeat flightless-interacting protein 2

Also known as: HUFI-2, LRRF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y608
Gene: LRRFIP2
Ensembl: ENSG00000093167
Chromosome: 3
Canonical length: 721 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Plasma membrane,Actin filaments

OverviewNCBI Gene

The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

721 residues, UniProt reviewed canonical sequence.

>Q9Y608|LRRFIP2
     1  MGTPASGRKR TPVKDRFSAE DEALSNIARE AEARLAAKRA ARAEARDIRM RELERQQKEY
    61  SLHSFDRKWG QIQKWLEDSE RARYSHRSSH HRPYLGVEDA LSIRSVGSHR YDMFKDRSSR
   121  LSSLNHSYSH SHGMKKRSSD SHKDLLSGLY FDQRNYSSLR HSKPTSAYYT RQSSSLYSDP
   181  LATYKSDRAS PTANSGLLRS ASLASLYNGG LYNPYGPRTP SECSYYSSRI SSARSSPGFT
   241  NDDTASIVSS DRASRGRRES VVSAADYFSR SNRRGSVVSE VDDISIPDLS SLDEKSDKQY
   301  AENYTRPSSR NSASATTPLS GNSSRRGSGD TSSLIDPDTS LSELRDIYDL KDQIQDVEGR
   361  YMQGLKELKE SLSEVEEKYK KAMVSNAQLD NEKNNLIYQV DTLKDVIEEQ EEQMAEFYRE
   421  NEEKSKELER QKHMCSVLQH KMEELKEGLR QRDELIEEKQ RMQQKIDTMT KEVFDLQETL
   481  LWKDKKIGAL EKQKEYIACL RNERDMLREE LADLQETVKT GEKHGLVIIP DGTPNGDVSH
   541  EPVAGAITVV SQEAAQVLES AGEGPLDVRL RKLAGEKEEL LSQIRKLKLQ LEEERQKCSR
   601  NDGTVGDLAG LQNGSDLQFI EMQRDANRQI SEYKFKLSKA EQDITTLEQS ISRLEGQVLR
   661  YKTAAENAEK VEDELKAEKR KLQRELRTAL DKIEEMEMTN SHLAKRLEKM KANRTALLAQ
   721  Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRFIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 89 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 89 nTPM
heart muscle: 69 nTPM
testis: 67 nTPM
esophagus: 51 nTPM
spinal cord: 47 nTPM
blood vessel: 45 nTPM

Single-cell type

esophageal apical cells: 1,232 nCPM
ocular epithelial cells: 688 nCPM
epididymal clear cells: 678 nCPM
suprabasal keratinocytes: 672 nCPM
myonuclei: 671 nCPM
epididymal basal cells: 667 nCPM

Immune cell

eosinophil: 34 nTPM
non-classical monocyte: 27 nTPM
classical monocyte: 21 nTPM
basophil: 20 nTPM
neutrophil: 19 nTPM
NK-cell: 17 nTPM

Brain region

white matter: 96 nTPM
basal ganglia: 69 nTPM
thalamus: 69 nTPM
medulla oblongata: 66 nTPM
hypothalamus: 65 nTPM
cerebellum: 63 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 0.71
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

LRR domain binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRFIP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRFIP2 as an antibody target. Whether an autoantibody or antibody against LRRFIP2 could matter depends on whether native LRRFIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRFIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRFIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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