Seroatlas · Human Serome Atlas

FLII

Protein flightless-1 homolog

Also known as: FLI, Fli1, FLII_HUMAN, FLIL, MGC39265

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13045
Gene: FLII
Ensembl: ENSG00000177731
Chromosome: 17
Canonical length: 1269 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centriolar satellite,Cytosol

OverviewNCBI Gene

This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1269 residues, UniProt reviewed canonical sequence.

>Q13045|FLII
     1  MEATGVLPFV RGVDLSGNDF KGGYFPENVK AMTSLRWLKL NRTGLCYLPE ELAALQKLEH
    61  LSVSHNNLTT LHGELSSLPS LRAIVARANS LKNSGVPDDI FKLDDLSVLD LSHNQLTECP
   121  RELENAKNML VLNLSHNSID TIPNQLFINL TDLLYLDLSE NRLESLPPQM RRLVHLQTLV
   181  LNGNPLLHAQ LRQLPAMTAL QTLHLRSTQR TQSNLPTSLE GLSNLADVDL SCNDLTRVPE
   241  CLYTLPSLRR LNLSSNQITE LSLCIDQWVH VETLNLSRNQ LTSLPSAICK LSKLKKLYLN
   301  SNKLDFDGLP SGIGKLTNLE EFMAANNNLE LVPESLCRCP KLRKLVLNKN HLVTLPEAIH
   361  FLTEIEVLDV RENPNLVMPP KPADRAAEWY NIDFSLQNQL RLAGASPATV AAAAAAGSGP
   421  KDPMARKMRL RRRKDSAQDD QAKQVLKGMS DVAQEKNKKQ EESADARAPS GKVRRWDQGL
   481  EKPRLDYSEF FTEDVGQLPG LTIWQIENFV PVLVEEAFHG KFYEADCYIV LKTFLDDSGS
   541  LNWEIYYWIG GEATLDKKAC SAIHAVNLRN YLGAECRTVR EEMGDESEEF LQVFDNDISY
   601  IEGGTASGFY TVEDTHYVTR MYRVYGKKNI KLEPVPLKGT SLDPRFVFLL DRGLDIYVWR
   661  GAQATLSSTT KARLFAEKIN KNERKGKAEI TLLVQGQELP EFWEALGGEP SEIKKHVPED
   721  FWPPQPKLYK VGLGLGYLEL PQINYKLSVE HKQRPKVELM PRMRLLQSLL DTRCVYILDC
   781  WSDVFIWLGR KSPRLVRAAA LKLGQELCGM LHRPRHATVS RSLEGTEAQV FKAKFKNWDD
   841  VLTVDYTRNA EAVLQSPGLS GKVKRDAEKK DQMKADLTAL FLPRQPPMSL AEAEQLMEEW
   901  NEDLDGMEGF VLEGKKFARL PEEEFGHFYT QDCYVFLCRY WVPVEYEEEE KKEDKEEKAE
   961  GKEGEEATAE AEEKQPEEDF QCIVYFWQGR EASNMGWLTF TFSLQKKFES LFPGKLEVVR
  1021  MTQQQENPKF LSHFKRKFII HRGKRKAVQG AQQPSLYQIR TNGSALCTRC IQINTDSSLL
  1081  NSEFCFILKV PFESEDNQGI VYAWVGRASD PDEAKLAEDI LNTMFDTSYS KQVINEGEEP
  1141  ENFFWVGIGA QKPYDDDAEY MKHTRLFRCS NEKGYFAVTE KCSDFCQDDL ADDDIMLLDN
  1201  GQEVYMWVGT QTSQVEIKLS LKACQVYIQH MRSKEHERPR RLRLVRKGNE QHAFTRCFHA
  1261  WSAFCKALA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FLII can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 240 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 240 nTPM
heart muscle: 74 nTPM
blood vessel: 71 nTPM
tongue: 68 nTPM
esophagus: 66 nTPM
salivary gland: 65 nTPM

Single-cell type

endometrial secretory cells: 24 nCPM
tuft cells: 23 nCPM
platelets: 23 nCPM
salivary duct cells: 21 nCPM
microglia: 20 nCPM
alveolar cells type 1: 20 nCPM

Immune cell

non-classical monocyte: 51 nTPM
intermediate monocyte: 39 nTPM
myeloid DC: 30 nTPM
classical monocyte: 28 nTPM
eosinophil: 26 nTPM
total PBMC: 24 nTPM

Brain region

medulla oblongata: 32 nTPM
pons: 32 nTPM
thalamus: 30 nTPM
choroid plexus: 28 nTPM
midbrain: 27 nTPM
white matter: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FLII.

Disease | AllUniProt

Conditions FLII is implicated in, by any mechanism.

Cardiomyopathy, dilated, 2J (CMD2J) MIM:620635

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 299 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Cardiomyopathy, dilated, 2j
Primary dilated cardiomyopathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0
gnomAD missense Z: 0.51
DepMap mean gene effect: -0.27
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FLII in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FLII as an antibody target. Whether an autoantibody or antibody against FLII could matter depends on whether native FLII is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FLII is annotated at the cell surface, where native FLII is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FLII as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...