Seroatlas · Human Serome Atlas

RNF41

E3 ubiquitin-protein ligase NRDP1

Also known as: NRDP1, RNF41_HUMAN, SBBI03

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H4P4
Gene: RNF41
Ensembl: ENSG00000181852
Chromosome: 12
Canonical length: 317 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Midbody ring

OverviewNCBI Gene

This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>Q9H4P4|RNF41
     1  MGYDVTRFQG DVDEDLICPI CSGVLEEPVQ APHCEHAFCN ACITQWFSQQ QTCPVDRSVV
    61  TVAHLRPVPR IMRNMLSKLQ IACDNAVFGC SAVVRLDNLM SHLSDCEHNP KRPVTCEQGC
   121  GLEMPKDELP NHNCIKHLRS VVQQQQTRIA ELEKTSAEHK HQLAEQKRDI QLLKAYMRAI
   181  RSVNPNLQNL EETIEYNEIL EWVNSLQPAR VTRWGGMIST PDAVLQAVIK RSLVESGCPA
   241  SIVNELIENA HERSWPQGLA TLETRQMNRR YYENYVAKRI PGKQAVVVMA CENQHMGDDM
   301  VQEPGLVMIF AHGVEEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF41 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

tongue: 38 nTPM
skeletal muscle: 32 nTPM
prostate: 32 nTPM
cerebral cortex: 31 nTPM
heart muscle: 31 nTPM
cerebellum: 31 nTPM

Single-cell type

early spermatids: 103 nCPM
late spermatids: 78 nCPM
late primary spermatocytes: 56 nCPM
neutrophils: 53 nCPM
hepatic stellate cells: 45 nCPM
adipocytes: 45 nCPM

Immune cell

eosinophil: 100 nTPM
basophil: 59 nTPM
naive B-cell: 55 nTPM
memory B-cell: 51 nTPM
neutrophil: 36 nTPM
NK-cell: 33 nTPM

Brain region

hypothalamus: 60 nTPM
cerebral cortex: 58 nTPM
basal ganglia: 55 nTPM
thalamus: 55 nTPM
pons: 53 nTPM
hippocampal formation: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.97
gnomAD missense Z: 3
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF41 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF41 as an antibody target. Whether an autoantibody or antibody against RNF41 could matter depends on whether native RNF41 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF41 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF41 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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