Seroatlas · Human Serome Atlas

TLR8

Toll-like receptor 8

Also known as: CD288, hTLR8, TLR8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NR97
Gene: TLR8
Ensembl: ENSG00000101916
Chromosome: X
Canonical length: 1041 aa
Protein class: CD markers, Disease related genes, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1041 residues, UniProt reviewed canonical sequence.

>Q9NR97|TLR8
     1  MENMFLQSSM LTCIFLLISG SCELCAEENF SRSYPCDEKK QNDSVIAECS NRRLQEVPQT
    61  VGKYVTELDL SDNFITHITN ESFQGLQNLT KINLNHNPNV QHQNGNPGIQ SNGLNITDGA
   121  FLNLKNLREL LLEDNQLPQI PSGLPESLTE LSLIQNNIYN ITKEGISRLI NLKNLYLAWN
   181  CYFNKVCEKT NIEDGVFETL TNLELLSLSF NSLSHVPPKL PSSLRKLFLS NTQIKYISEE
   241  DFKGLINLTL LDLSGNCPRC FNAPFPCVPC DGGASINIDR FAFQNLTQLR YLNLSSTSLR
   301  KINAAWFKNM PHLKVLDLEF NYLVGEIASG AFLTMLPRLE ILDLSFNYIK GSYPQHINIS
   361  RNFSKLLSLR ALHLRGYVFQ ELREDDFQPL MQLPNLSTIN LGINFIKQID FKLFQNFSNL
   421  EIIYLSENRI SPLVKDTRQS YANSSSFQRH IRKRRSTDFE FDPHSNFYHF TRPLIKPQCA
   481  AYGKALDLSL NSIFFIGPNQ FENLPDIACL NLSANSNAQV LSGTEFSAIP HVKYLDLTNN
   541  RLDFDNASAL TELSDLEVLD LSYNSHYFRI AGVTHHLEFI QNFTNLKVLN LSHNNIYTLT
   601  DKYNLESKSL VELVFSGNRL DILWNDDDNR YISIFKGLKN LTRLDLSLNR LKHIPNEAFL
   661  NLPASLTELH INDNMLKFFN WTLLQQFPRL ELLDLRGNKL LFLTDSLSDF TSSLRTLLLS
   721  HNRISHLPSG FLSEVSSLKH LDLSSNLLKT INKSALETKT TTKLSMLELH GNPFECTCDI
   781  GDFRRWMDEH LNVKIPRLVD VICASPGDQR GKSIVSLELT TCVSDVTAVI LFFFTFFITT
   841  MVMLAALAHH LFYWDVWFIY NVCLAKVKGY RSLSTSQTFY DAYISYDTKD ASVTDWVINE
   901  LRYHLEESRD KNVLLCLEER DWDPGLAIID NLMQSINQSK KTVFVLTKKY AKSWNFKTAF
   961  YLALQRLMDE NMDVIIFILL EPVLQHSQYL RLRQRICKSS ILQWPDNPKA EGLFWQTLRN
  1021  VVLTENDSRY NNMYVDSIKQ Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TLR8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

appendix: 16 nTPM
spleen: 13 nTPM
lung: 10 nTPM
lymph node: 5.7 nTPM
bone marrow: 5.4 nTPM
placenta: 4 nTPM

Single-cell type

neutrophils: 338 nCPM
monocytes: 69 nCPM
kupffer cells: 58 nCPM
neutrophil progenitors: 42 nCPM
monocyte progenitors: 36 nCPM
macrophages: 23 nCPM

Immune cell

neutrophil: 28 nTPM
classical monocyte: 17 nTPM
non-classical monocyte: 16 nTPM
intermediate monocyte: 15 nTPM
myeloid DC: 8.4 nTPM
total PBMC: 3.8 nTPM

Brain region

medulla oblongata: 2.4 nTPM
white matter: 1.8 nTPM
pons: 1.7 nTPM
choroid plexus: 1.2 nTPM
spinal cord: 1.2 nTPM
thalamus: 1.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TLR8.

Disease | AllUniProt

Conditions TLR8 is implicated in, by any mechanism.

Immunodeficiency 98 with autoinflammation, X-linked (IMD98) MIM:301078

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 137 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Immunodeficiency 98 with autoinflammation, X-linked
INFLTR8
Autoimmune hemolytic anemia
Systemic autoinflammation

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.32
gnomAD missense Z: 3.08
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TLR8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TLR8 as an antibody target. Whether an autoantibody or antibody against TLR8 could matter depends on whether native TLR8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TLR8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TLR8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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