Seroatlas · Human Serome Atlas

IRAK2

Interleukin-1 receptor-associated kinase-like 2

Also known as: IRAK2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43187
Gene
IRAK2
Ensembl
ENSG00000134070
Chromosome
3
Canonical length
625 aa
Protein class
Enzymes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

625 residues, UniProt reviewed canonical sequence.

>O43187|IRAK2
     1  MACYIYQLPS WVLDDLCRNM DALSEWDWME FASYVITDLT QLRKIKSMER VQGVSITREL
    61  LWWWGMRQAT VQQLVDLLCR LELYRAAQII LNWKPAPEIR CPIPAFPDSV KPEKPLAASV
   121  RKAEDEQEEG QPVRMATFPG PGSSPARAHQ PAFLQPPEED APHSLRSDLP TSSDSKDFST
   181  SIPKQEKLLS LAGDSLFWSE ADVVQATDDF NQNRKISQGT FADVYRGHRH GKPFVFKKLR
   241  ETACSSPGSI ERFFQAELQI CLRCCHPNVL PVLGFCAARQ FHSFIYPYMA NGSLQDRLQG
   301  QGGSDPLPWP QRVSICSGLL CAVEYLHGLE IIHSNVKSSN VLLDQNLTPK LAHPMAHLCP
   361  VNKRSKYTMM KTHLLRTSAA YLPEDFIRVG QLTKRVDIFS CGIVLAEVLT GIPAMDNNRS
   421  PVYLKDLLLS DIPSSTASLC SRKTGVENVM AKEICQKYLE KGAGRLPEDC AEALATAACL
   481  CLRRRNTSLQ EVCGSVAAVE ERLRGRETLL PWSGLSEGTG SSSNTPEETD DVDNSSLDAS
   541  SSMSVAPWAG AATPLLPTEN GEGRLRVIVG READSSSEAC VGLEPPQDVT ETSWQIEINE
   601  AKRKLMENIL LYKEEKVDSI ELFGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IRAK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 22 nTPM
  • skeletal muscle: 16 nTPM
  • urinary bladder: 15 nTPM
  • tonsil: 11 nTPM
  • liver: 10 nTPM
  • lung: 10 nTPM

Single-cell type

  • neutrophils: 783 nCPM
  • urothelial cells: 464 nCPM
  • monocytes: 315 nCPM
  • cdc: 153 nCPM
  • endometrial glandular cells: 143 nCPM
  • macrophages: 132 nCPM

Immune cell

  • NK-cell: 7.4 nTPM
  • MAIT T-cell: 6 nTPM
  • gdT-cell: 5.8 nTPM
  • memory B-cell: 4.2 nTPM
  • memory CD8 T-cell: 3.3 nTPM
  • naive B-cell: 3.2 nTPM

Brain region

  • cerebral cortex: 18 nTPM
  • white matter: 17 nTPM
  • pons: 13 nTPM
  • hypothalamus: 12 nTPM
  • medulla oblongata: 12 nTPM
  • thalamus: 9.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0
gnomAD missense Z
-0.06
DepMap mean gene effect
0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IRAK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IRAK2 as an antibody target. Whether an autoantibody or antibody against IRAK2 could matter depends on whether native IRAK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IRAK2 is annotated at the cell surface, where native IRAK2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IRAK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IRAK2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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