Seroatlas · Human Serome Atlas

IL18R1

Interleukin-18 receptor 1

Also known as: CD218a, IL-1Rrp, IL18R_HUMAN, IL1RRP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13478
Gene
IL18R1
Ensembl
ENSG00000115604
Chromosome
2
Canonical length
541 aa
Protein class
CD markers, Enzymes, Plasma proteins, Predicted membrane proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

541 residues, UniProt reviewed canonical sequence.

>Q13478|IL18R1
     1  MNCRELPLTL WVLISVSTAE SCTSRPHITV VEGEPFYLKH CSCSLAHEIE TTTKSWYKSS
    61  GSQEHVELNP RSSSRIALHD CVLEFWPVEL NDTGSYFFQM KNYTQKWKLN VIRRNKHSCF
   121  TERQVTSKIV EVKKFFQITC ENSYYQTLVN STSLYKNCKK LLLENNKNPT IKKNAEFEDQ
   181  GYYSCVHFLH HNGKLFNITK TFNITIVEDR SNIVPVLLGP KLNHVAVELG KNVRLNCSAL
   241  LNEEDVIYWM FGEENGSDPN IHEEKEMRIM TPEGKWHASK VLRIENIGES NLNVLYNCTV
   301  ASTGGTDTKS FILVRKADMA DIPGHVFTRG MIIAVLILVA VVCLVTVCVI YRVDLVLFYR
   361  HLTRRDETLT DGKTYDAFVS YLKECRPENG EEHTFAVEIL PRVLEKHFGY KLCIFERDVV
   421  PGGAVVDEIH SLIEKSRRLI IVLSKSYMSN EVRYELESGL HEALVERKIK IILIEFTPVT
   481  DFTFLPQSLK LLKSHRVLKW KADKSLSYNS RFWKNLLYLM PAKTVKPGRD EPEVLPVLSE
   541  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL18R1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • lung: 11 nTPM
  • placenta: 6.4 nTPM
  • liver: 6.1 nTPM
  • appendix: 5.3 nTPM
  • seminal vesicle: 5.3 nTPM
  • cervix: 4.3 nTPM

Single-cell type

  • neutrophils: 3,313 nCPM
  • mast cells: 1,308 nCPM
  • innate lymphoid cells: 284 nCPM
  • neutrophil progenitors: 221 nCPM
  • cdc: 106 nCPM
  • t-cells: 99 nCPM

Immune cell

  • NK-cell: 46 nTPM
  • MAIT T-cell: 16 nTPM
  • plasmacytoid DC: 10 nTPM
  • basophil: 10 nTPM
  • neutrophil: 6.7 nTPM
  • gdT-cell: 6.2 nTPM

Brain region

  • hypothalamus: 3.6 nTPM
  • cerebral cortex: 3.1 nTPM
  • thalamus: 2.8 nTPM
  • pons: 2.6 nTPM
  • choroid plexus: 2 nTPM
  • medulla oblongata: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0
gnomAD missense Z
0.97
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IL18R1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL18R1 as an antibody target. Whether an autoantibody or antibody against IL18R1 could matter depends on whether native IL18R1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL18R1 is annotated at the cell surface, where native IL18R1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IL18R1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IL18R1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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