NEK10

Protein identityUniProt · HPA

UniProt accession

Q6ZWH5

Gene

NEK10

Ensembl

ENSG00000163491

Chromosome

3

Canonical length

1172 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Vesicles

OverviewNCBI Gene

Enables protein kinase activity. Involved in several processes, including mucociliary clearance; positive regulation of protein phosphorylation; and regulation of ERK1 and ERK2 cascade. Part of protein kinase complex. Implicated in primary ciliary dyskinesia 44. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1172 residues, UniProt reviewed canonical sequence.

>Q6ZWH5|NEK10
     1  MPDQDKKVKT TEKSTDKQQE ITIRDYSDLK RLRCLLNVQS SKQQLPAINF DSAQNSMTKS
    61  EPAIRAGGHR ARGQWHESTE AVELENFSIN YKNERNFSKH PQRKLFQEIF TALVKNRLIS
   121  REWVNRAPSI HFLRVLICLR LLMRDPCYQE ILHSLGGIEN LAQYMEIVAN EYLGYGEEQH
   181  TVDKLVNMTY IFQKLAAVKD QREWVTTSGA HKTLVNLLGA RDTNVLLGSL LALASLAESQ
   241  ECREKISELN IVENLLMILH EYDLLSKRLT AELLRLLCAE PQVKEQVKLY EGIPVLLSLL
   301  HSDHLKLLWS IVWILVQVCE DPETSVEIRI WGGIKQLLHI LQGDRNFVSD HSSIGSLSSA
   361  NAAGRIQQLH LSEDLSPREI QENTFSLQAA CCAALTELVL NDTNAHQVVQ ENGVYTIAKL
   421  ILPNKQKNAA KSNLLQCYAF RALRFLFSME RNRPLFKRLF PTDLFEIFID IGHYVRDISA
   481  YEELVSKLNL LVEDELKQIA ENIESINQNK APLKYIGNYA ILDHLGSGAF GCVYKVRKHS
   541  GQNLLAMKEV NLHNPAFGKD KKDRDSSVRN IVSELTIIKE QLYHPNIVRY YKTFLENDRL
   601  YIVMELIEGA PLGEHFSSLK EKHHHFTEER LWKIFIQLCL ALRYLHKEKR IVHRDLTPNN
   661  IMLGDKDKVT VTDFGLAKQK QENSKLTSVV GTILYSCPEV LKSEPYGEKA DVWAVGCILY
   721  QMATLSPPFY STNMLSLATK IVEAVYEPVP EGIYSEKVTD TISRCLTPDA EARPDIVEVS
   781  SMISDVMMKY LDNLSTSQLS LEKKLERERR RTQRYFMEAN RNTVTCHHEL AVLSHETFEK
   841  ASLSSSSSGA ASLKSELSES ADLPPEGFQA SYGKDEDRAC DEILSDDNFN LENAEKDTYS
   901  EVDDELDISD NSSSSSSSPL KESTFNILKR SFSASGGERQ SQTRDFTGGT GSRPRPALLP
   961  LDLLLKVPPH MLRAHIKEIE AELVTGWQSH SLPAVILRNL KDHGPQMGTF LWQASAGIAV
  1021  SQRKVRQISD PIQQILIQLH KIIYITQLPP ALHHNLKRRV IERFKKSLFS QQSNPCNLKS
  1081  EIKKLSQGSP EPIEPNFFTA DYHLLHRSSG GNSLSPNDPT GLPTSIELEE GITYEQMQTV
  1141  IEEVLEESGY YNFTSNRYHS YPWGTKNHPT KR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEK10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

33 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NEK10.

Disease | AllUniProt

Conditions NEK10 is implicated in, by any mechanism.

• Ciliary dyskinesia, primary, 44 (CILD44) MIM:618781

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 113 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Ciliary dyskinesia, primary, 44
• Primary ciliary dyskinesia

Disease | ImmuneIEDB

Conditions an epitope on NEK10 was assayed in.

• narcolepsy B cell
• multiple sclerosis B cell
• peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.74

gnomAD pLI

0

gnomAD missense Z

0.62

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• mucociliary clearance
• positive regulation of MAP kinase activity
• positive regulation of protein autophosphorylation
• protein phosphorylation
• regulation of cell cycle G2/M phase transition
• regulation of ERK1 and ERK2 cascade

Molecular functions

• ATP binding
• metal ion binding
• protein kinase activity
• protein serine kinase activity
• protein serine/threonine kinase activity

Cellular components

• extracellular region
• protein kinase complex

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Tyrosine-protein kinase, active site
• Protein kinase-like domain superfamily
• Armadillo-like helical
• Armadillo-type fold
• Protein kinase, ATP binding site
• Protein kinase domain
• Serine/threonine-protein kinase Nek10, catalytic domain
• NEK Serine/Threonine Protein Kinase

KeywordsUniProt

• ATP-binding
• Ciliopathy
• Coiled coil
• Kinase
• Magnesium
• Metal-binding
• Nucleotide-binding
• Primary ciliary dyskinesia
• Serine/threonine-protein kinase
• Transferase

InteractionsUniProt · HPA

Protein binding partners of NEK10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAP2K1
• RAF1