Seroatlas · Human Serome Atlas

SESN2

Sestrin-2

Also known as: DKFZp761M0212, HI95, SES2, SESN2_HUMAN, SEST2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P58004
Gene
SESN2
Ensembl
ENSG00000130766
Chromosome
1
Canonical length
480 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

480 residues, UniProt reviewed canonical sequence.

>P58004|SESN2
     1  MIVADSECRA ELKDYLRFAP GGVGDSGPGE EQRESRARRG PRGPSAFIPV EEVLREGAES
    61  LEQHLGLEAL MSSGRVDNLA VVMGLHPDYF TSFWRLHYLL LHTDGPLASS WRHYIAIMAA
   121  ARHQCSYLVG SHMAEFLQTG GDPEWLLGLH RAPEKLRKLS EINKLLAHRP WLITKEHIQA
   181  LLKTGEHTWS LAELIQALVL LTHCHSLSSF VFGCGILPEG DADGSPAPQA PTPPSEQSSP
   241  PSRDPLNNSG GFESARDVEA LMERMQQLQE SLLRDEGTSQ EEMESRFELE KSESLLVTPS
   301  ADILEPSPHP DMLCFVEDPT FGYEDFTRRG AQAPPTFRAQ DYTWEDHGYS LIQRLYPEGG
   361  QLLDEKFQAA YSLTYNTIAM HSGVDTSVLR RAIWNYIHCV FGIRYDDYDY GEVNQLLERN
   421  LKVYIKTVAC YPEKTTRRMY NLFWRHFRHS EKVHVNLLLL EARMQAALLY ALRAITRYMT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SESN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 26 nTPM
  • liver: 23 nTPM
  • esophagus: 19 nTPM
  • bone marrow: 18 nTPM
  • kidney: 15 nTPM
  • adipose tissue: 11 nTPM

Single-cell type

  • proximal tubule cells: 47 nCPM
  • podocytes: 12 nCPM
  • choroid plexus epithelial cells: 12 nCPM
  • papillary tip epithelial cells: 11 nCPM
  • renal connecting tubule cells: 11 nCPM
  • loop of henle epithelial cells: 9.9 nCPM

Immune cell

  • gdT-cell: 5.7 nTPM
  • neutrophil: 3.9 nTPM
  • memory CD8 T-cell: 2.8 nTPM
  • MAIT T-cell: 2.7 nTPM
  • naive CD8 T-cell: 2.5 nTPM
  • NK-cell: 2.5 nTPM

Brain region

  • thalamus: 13 nTPM
  • midbrain: 9.3 nTPM
  • medulla oblongata: 8.9 nTPM
  • hypothalamus: 8.2 nTPM
  • white matter: 7.9 nTPM
  • pons: 7.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0
gnomAD missense Z
1.65
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SESN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SESN2 as an antibody target. Whether an autoantibody or antibody against SESN2 could matter depends on whether native SESN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SESN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SESN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SESN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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