PTMA
Prothymosin alpha
Also known as: PTMA_HUMAN, TMSA
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P06454
- Gene
- PTMA
- Ensembl
- ENSG00000187514
- Chromosome
- 2
- Canonical length
- 111 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Enables DNA-binding transcription factor binding activity and histone binding activity. Involved in negative regulation of apoptotic process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
111 residues, UniProt reviewed canonical sequence.
>P06454|PTMA
1 MSDAAVDTSS EITTKDLKEK KEVVEEAENG RDAPANGNAE NEENGEQEAD NEVDEEEEEG
61 GEEEEEEEEG DGEEEDGDED EEAESATGKR AAEDDEDDDV DTKKQKTDED DLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PTMA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.69
- Highest tissue expression
- 2,191 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 2,191 nTPM
- thymus: 1,918 nTPM
- blood vessel: 1,538 nTPM
- tonsil: 1,426 nTPM
- skin: 1,367 nTPM
- lymph node: 1,304 nTPM
Single-cell type
- esophageal basal cells: 6,616 nCPM
- gastric progenitor cells: 6,567 nCPM
- basal keratinocytes: 5,802 nCPM
- enteric transient amplifying cells: 5,259 nCPM
- epididymal efferent duct absorptive cells: 5,067 nCPM
- megakaryocytes: 5,057 nCPM
Immune cell
- total PBMC: 4,655 nTPM
- memory B-cell: 2,787 nTPM
- T-reg: 2,513 nTPM
- naive B-cell: 2,450 nTPM
- naive CD4 T-cell: 2,115 nTPM
- basophil: 2,069 nTPM
Brain region
- white matter: 1,365 nTPM
- basal ganglia: 1,125 nTPM
- medulla oblongata: 1,015 nTPM
- midbrain: 962 nTPM
- thalamus: 945 nTPM
- hypothalamus: 880 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.23
- gnomAD pLI
- 0.03
- gnomAD missense Z
- 0.26
- DepMap mean gene effect
- -0.44
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- chromatin organization
- DNA-templated transcription
- negative regulation of apoptotic process
- positive regulation of transcription by RNA polymerase II
Molecular functions
- calcium ion binding
- DNA-binding transcription factor binding
- histone binding
- histone chaperone activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PTMA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PTMA as an antibody target. Whether an autoantibody or antibody against PTMA could matter depends on whether native PTMA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PTMA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PTMA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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