Seroatlas · Human Serome Atlas

PGCKA1

PDCD10 and GCKIII kinases-associated protein 1

Also known as: C4orf19, FLJ11017, PGKA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IY42
Gene: PGCKA1
Ensembl: ENSG00000154274
Chromosome: 4
Canonical length: 314 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cell Junctions

OverviewNCBI Gene

No narrative summary is available for PGCKA1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>Q8IY42|PGCKA1
     1  MGCRCCKIIQ SYLFDPVQVP SPGYVNEVNS CKLDEDDTDK LKGKWSSEVL VQKNDPQRQG
    61  SKKTESSSRT ADPWEPCWPH QGPLPQGDAG GEHHACGVNG IGPAATPQPT GNSSPTQDDR
   121  GSWASTANTV PPTQPFLEGG GTRKQDCVLL ASEGTQVMRN GDSRAPSEAE SFALEVQDHV
   181  FQIPAPDYLQ HWGPAGDNVD HNEKDCVFKN HTEDESLEGI QPPVGEHGLN TPFSVRRSWD
   241  SLNEDVETEV LSICFNEKGP VHAMPVVDSG NRQEDTHGSD GDGDGEIVDE DAAVAEALAA
   301  LEAATAGEDL DETD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGCKA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

liver: 34 nTPM
salivary gland: 27 nTPM
colon: 24 nTPM
rectum: 22 nTPM
pancreas: 22 nTPM
stomach: 20 nTPM

Single-cell type

epicardial cells: 523 nCPM
renal connecting tubule cells: 422 nCPM
distal convoluted tubule cells: 385 nCPM
cholangiocytes: 325 nCPM
parietal cells: 324 nCPM
syncytiotrophoblasts: 306 nCPM

Immune cell

neutrophil: 8.4 nTPM
eosinophil: 2.1 nTPM
plasmacytoid DC: 1.5 nTPM
classical monocyte: 1.4 nTPM
basophil: 0.8 nTPM
naive CD8 T-cell: 0.8 nTPM

Brain region

choroid plexus: 13 nTPM
cerebellum: 12 nTPM
medulla oblongata: 11 nTPM
midbrain: 11 nTPM
thalamus: 11 nTPM
spinal cord: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0.09
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of cell cycle

Cellular components

Protein domainsUniProt · Pfam · InterPro

PDCD10 and GCKIII kinases-associated protein 1 C4orf19/PGCKA1
Domain of unknown function (DUF4699)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PGCKA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PGCKA1 as an antibody target. Whether an autoantibody or antibody against PGCKA1 could matter depends on whether native PGCKA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PGCKA1 is annotated at the cell surface, where native PGCKA1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PGCKA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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