Seroatlas · Human Serome Atlas

NIBAN2

Protein Niban 2

Also known as: bA356B19.6, C9orf88, DKFZP434H0820, FAM129B, FLJ13518, FLJ22151, FLJ22298, MINERVA, NIBA2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96TA1
Gene: NIBAN2
Ensembl: ENSG00000136830
Chromosome: 9
Canonical length: 746 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables transcription coactivator activity. Involved in several processes, including gonadotropin secretion; negative regulation of apoptotic process; and regulation of nucleobase-containing compound metabolic process. Located in several cellular components, including adherens junction; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

746 residues, UniProt reviewed canonical sequence.

>Q96TA1|NIBAN2
     1  MGDVLSTHLD DARRQHIAEK TGKILTEFLQ FYEDQYGVAL FNSMRHEIEG TGLPQAQLLW
    61  RKVPLDERIV FSGNLFQHQE DSKKWRNRFS LVPHNYGLVL YENKAAYERQ VPPRAVINSA
   121  GYKILTSVDQ YLELIGNSLP GTTAKSGSAP ILKCPTQFPL ILWHPYARHY YFCMMTEAEQ
   181  DKWQAVLQDC IRHCNNGIPE DSKVEGPAFT DAIRMYRQSK ELYGTWEMLC GNEVQILSNL
   241  VMEELGPELK AELGPRLKGK PQERQRQWIQ ISDAVYHMVY EQAKARFEEV LSKVQQVQPA
   301  MQAVIRTDMD QIITSKEHLA SKIRAFILPK AEVCVRNHVQ PYIPSILEAL MVPTSQGFTE
   361  VRDVFFKEVT DMNLNVINEG GIDKLGEYME KLSRLAYHPL KMQSCYEKME SLRLDGLQQR
   421  FDVSSTSVFK QRAQIHMREQ MDNAVYTFET LLHQELGKGP TKEELCKSIQ RVLERVLKKY
   481  DYDSSSVRKR FFREALLQIS IPFLLKKLAP TCKSELPRFQ ELIFEDFARF ILVENTYEEV
   541  VLQTVMKDIL QAVKEAAVQR KHNLYRDSMV MHNSDPNLHL LAEGAPIDWG EEYSNSGGGG
   601  SPSPSTPESA TLSEKRRRAK QVVSVVQDEE VGLPFEASPE SPPPASPDGV TEIRGLLAQG
   661  LRPESPPPAG PLLNGAPAGE SPQPKAAPEA SSPPASPLQH LLPGKAVDLG PPKPSDQETG
   721  EQVSSPSSHP ALHTTTEDSA GVQTEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NIBAN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 592 nTPM

Expression across tissuesHPA

Tissue

esophagus: 592 nTPM
vagina: 180 nTPM
cervix: 154 nTPM
pancreas: 137 nTPM
salivary gland: 133 nTPM
lung: 117 nTPM

Single-cell type

esophageal apical cells: 2,283 nCPM
esophageal suprabasal cells: 458 nCPM
alveolar cells type 1: 249 nCPM
alveolar cells type 2: 246 nCPM
endometrial glandular cells: 235 nCPM
transitional alveolar cells: 229 nCPM

Immune cell

classical monocyte: 1.1 nTPM
myeloid DC: 0.7 nTPM
total PBMC: 0.7 nTPM
intermediate monocyte: 0.4 nTPM
basophil: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

medulla oblongata: 83 nTPM
choroid plexus: 75 nTPM
spinal cord: 63 nTPM
hypothalamus: 54 nTPM
thalamus: 53 nTPM
pons: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.02
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NIBAN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KEAP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NIBAN2 as an antibody target. Whether an autoantibody or antibody against NIBAN2 could matter depends on whether native NIBAN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NIBAN2 is annotated at the cell surface, where native NIBAN2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NIBAN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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