Seroatlas · Human Serome Atlas

DPP3

Dipeptidyl peptidase 3

Also known as: DPP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NY33
Gene: DPP3
Ensembl: ENSG00000254986
Chromosome: 11
Canonical length: 737 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

737 residues, UniProt reviewed canonical sequence.

>Q9NY33|DPP3
     1  MADTQYILPN DIGVSSLDCR EAFRLLSPTE RLYAYHLSRA AWYGGLAVLL QTSPEAPYIY
    61  ALLSRLFRAQ DPDQLRQHAL AEGLTEEEYQ AFLVYAAGVY SNMGNYKSFG DTKFVPNLPK
   121  EKLERVILGS EAAQQHPEEV RGLWQTCGEL MFSLEPRLRH LGLGKEGITT YFSGNCTMED
   181  AKLAQDFLDS QNLSAYNTRL FKEVDGEGKP YYEVRLASVL GSEPSLDSEV TSKLKSYEFR
   241  GSPFQVTRGD YAPILQKVVE QLEKAKAYAA NSHQGQMLAQ YIESFTQGSI EAHKRGSRFW
   301  IQDKGPIVES YIGFIESYRD PFGSRGEFEG FVAVVNKAMS AKFERLVASA EQLLKELPWP
   361  PTFEKDKFLT PDFTSLDVLT FAGSGIPAGI NIPNYDDLRQ TEGFKNVSLG NVLAVAYATQ
   421  REKLTFLEED DKDLYILWKG PSFDVQVGLH ELLGHGSGKL FVQDEKGAFN FDQETVINPE
   481  TGEQIQSWYR SGETWDSKFS TIASSYEECR AESVGLYLCL HPQVLEIFGF EGADAEDVIY
   541  VNWLNMVRAG LLALEFYTPE AFNWRQAHMQ ARFVILRVLL EAGEGLVTIT PTTGSDGRPD
   601  ARVRLDRSKI RSVGKPALER FLRRLQVLKS TGDVAGGRAL YEGYATVTDA PPECFLTLRD
   661  TVLLRKESRK LIVQPNTRLE GSDVQLLEYE ASAAGLIRSF SERFPEDGPE LEEILTQLAT
   721  ADARFWKGPS EAPSGQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.2
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

colon: 27 nTPM
skeletal muscle: 25 nTPM
rectum: 24 nTPM
duodenum: 23 nTPM
esophagus: 22 nTPM
tonsil: 22 nTPM

Single-cell type

rod photoreceptor cells: 19 nCPM
oocytes: 14 nCPM
thymocytes: 13 nCPM
adrenal medulla cells: 11 nCPM
retinal horizontal cells: 10 nCPM
oligodendrocytes: 8.3 nCPM

Immune cell

intermediate monocyte: 38 nTPM
myeloid DC: 31 nTPM
NK-cell: 30 nTPM
T-reg: 29 nTPM
non-classical monocyte: 28 nTPM
plasmacytoid DC: 22 nTPM

Brain region

pons: 21 nTPM
cerebral cortex: 20 nTPM
medulla oblongata: 19 nTPM
thalamus: 19 nTPM
cerebellum: 18 nTPM
white matter: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
gnomAD missense Z: 1.29
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Dipeptidyl-peptidase 3
Peptidase family M49
Peptidase family M49

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DPP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KEAP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DPP3 as an antibody target. Whether an autoantibody or antibody against DPP3 could matter depends on whether native DPP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DPP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DPP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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