Seroatlas · Human Serome Atlas

NFE2L1

Endoplasmic reticulum membrane sensor NFE2L1

Also known as: FLJ00380, LCR-F1, NF2L1_HUMAN, NRF-1, NRF1, TCF11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14494
Gene
NFE2L1
Ensembl
ENSG00000082641
Chromosome
17
Canonical length
772 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for """"""""""""""""""""""""""""""""nuclear respiratory factor 1"""""""""""""""""""""""""""""""" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

772 residues, UniProt reviewed canonical sequence.

>Q14494|NFE2L1
     1  MLSLKKYLTE GLLQFTILLS LIGVRVDVDT YLTSQLPPLR EIILGPSSAY TQTQFHNLRN
    61  TLDGYGIHPK SIDLDNYFTA RRLLSQVRAL DRFQVPTTEV NAWLVHRDPE GSVSGSQPNS
   121  GLALESSSGL QDVTGPDNGV RESETEQGFG EDLEDLGAVA PPVSGDLTKE DIDLIDILWR
   181  QDIDLGAGRE VFDYSHRQKE QDVEKELRDG GEQDTWAGEG AEALARNLLV DGETGESFPA
   241  QVPSGEDQTA LSLEECLRLL EATCPFGENA EFPADISSIT EAVPSESEPP ALQNNLLSPL
   301  LTGTESPFDL EQQWQDLMSI MEMQAMEVNT SASEILYSAP PGDPLSTNYS LAPNTPINQN
   361  VSLHQASLGG CSQDFLLFSP EVESLPVASS STLLPLAPSN STSLNSTFGS TNLTGLFFPP
   421  QLNGTANDTA GPELPDPLGG LLDEAMLDEI SLMDLAIEEG FNPVQASQLE EEFDSDSGLS
   481  LDSSHSPSSL SSSEGSSSSS SSSSSSSSSA SSSASSSFSE EGAVGYSSDS ETLDLEEAEG
   541  AVGYQPEYSK FCRMSYQDPA QLSCLPYLEH VGHNHTYNMA PSALDSADLP PPSALKKGSK
   601  EKQADFLDKQ MSRDEHRARA MKIPFTNDKI INLPVEEFNE LLSKYQLSEA QLSLIRDIRR
   661  RGKNKMAAQN CRKRKLDTIL NLERDVEDLQ RDKARLLREK VEFLRSLRQM KQKVQSLYQE
   721  VFGRLRDENG RPYSPSQYAL QYAGDGSVLL IPRTMADQQA RRQERKPKDR RK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NFE2L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
1,273 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 1,273 nTPM
  • tongue: 801 nTPM
  • heart muscle: 403 nTPM
  • choroid plexus: 230 nTPM
  • kidney: 149 nTPM
  • blood vessel: 147 nTPM

Single-cell type

  • thymic myoid cells: 354 nCPM
  • corticotrophs: 167 nCPM
  • hepatocytes: 140 nCPM
  • retinal pigment epithelial cells: 132 nCPM
  • myonuclei: 129 nCPM
  • epididymal efferent duct ciliated cells: 126 nCPM

Immune cell

  • neutrophil: 26 nTPM
  • basophil: 14 nTPM
  • plasmacytoid DC: 13 nTPM
  • classical monocyte: 12 nTPM
  • non-classical monocyte: 8.8 nTPM
  • intermediate monocyte: 6.5 nTPM

Brain region

  • choroid plexus: 477 nTPM
  • hypothalamus: 316 nTPM
  • white matter: 287 nTPM
  • midbrain: 285 nTPM
  • pons: 283 nTPM
  • medulla oblongata: 276 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
1
gnomAD missense Z
1.76
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NFE2L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NFE2L1 as an antibody target. Whether an autoantibody or antibody against NFE2L1 could matter depends on whether native NFE2L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NFE2L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NFE2L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NFE2L1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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