Seroatlas · Human Serome Atlas

SESN1

Sestrin-1

Also known as: PA26, SESN1_HUMAN, SEST1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6P5
Gene
SESN1
Ensembl
ENSG00000080546
Chromosome
6
Canonical length
492 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

492 residues, UniProt reviewed canonical sequence.

>Q9Y6P5|SESN1
     1  MRLAAAANEA YTAPLAVSGL LGCKQCGGGR DQDEELGIRI PRPLGQGPSR FIPEKEILQV
    61  GSEDAQMHAL FADSFAALGR LDNITLVMVF HPQYLESFLK TQHYLLQMDG PLPLHYRHYI
   121  GIMAAARHQC SYLVNLHVND FLHVGGDPKW LNGLENAPQK LQNLGELNKV LAHRPWLITK
   181  EHIEGLLKAE EHSWSLAELV HAVVLLTHYH SLASFTFGCG ISPEIHCDGG HTFRPPSVSN
   241  YCICDITNGN HSVDEMPVNS AENVSVSDSF FEVEALMEKM RQLQECRDEE EASQEEMASR
   301  FEIEKRESMF VFSSDDEEVT PARAVSRHFE DTSYGYKDFS RHGMHVPTFR VQDYCWEDHG
   361  YSLVNRLYPD VGQLIDEKFH IAYNLTYNTM AMHKDVDTSM LRRAIWNYIH CMFGIRYDDY
   421  DYGEINQLLD RSFKVYIKTV VCTPEKVTKR MYDSFWRQFK HSEKVHVNLL LIEARMQAEL
   481  LYALRAITRY MT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SESN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
140 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 140 nTPM
  • tongue: 130 nTPM
  • placenta: 50 nTPM
  • bone marrow: 47 nTPM
  • parathyroid gland: 47 nTPM
  • ovary: 47 nTPM

Single-cell type

  • myonuclei: 1,615 nCPM
  • thymic myoid cells: 568 nCPM
  • sertoli cells: 396 nCPM
  • cardiomyocytes: 339 nCPM
  • innate lymphoid cells: 252 nCPM
  • macrophages: 249 nCPM

Immune cell

  • MAIT T-cell: 75 nTPM
  • NK-cell: 59 nTPM
  • naive B-cell: 48 nTPM
  • naive CD4 T-cell: 40 nTPM
  • gdT-cell: 34 nTPM
  • memory CD4 T-cell: 32 nTPM

Brain region

  • white matter: 31 nTPM
  • cerebral cortex: 30 nTPM
  • basal ganglia: 29 nTPM
  • choroid plexus: 29 nTPM
  • thalamus: 29 nTPM
  • cerebellum: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0
gnomAD missense Z
1.05
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SESN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SESN1 as an antibody target. Whether an autoantibody or antibody against SESN1 could matter depends on whether native SESN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SESN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SESN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SESN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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