Seroatlas · Human Serome Atlas

ETF1

Eukaryotic peptide chain release factor subunit 1

Also known as: ERF, ERF1, ERF1_HUMAN, RF1, SUP45L1, TB3-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62495
Gene
ETF1
Ensembl
ENSG00000120705
Chromosome
5
Canonical length
437 aa
Protein class
Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

437 residues, UniProt reviewed canonical sequence.

>P62495|ETF1
     1  MADDPSAADR NVEIWKIKKL IKSLEAARGN GTSMISLIIP PKDQISRVAK MLADEFGTAS
    61  NIKSRVNRLS VLGAITSVQQ RLKLYNKVPP NGLVVYCGTI VTEEGKEKKV NIDFEPFKPI
   121  NTSLYLCDNK FHTEALTALL SDDSKFGFIV IDGSGALFGT LQGNTREVLH KFTVDLPKKH
   181  GRGGQSALRF ARLRMEKRHN YVRKVAETAV QLFISGDKVN VAGLVLAGSA DFKTELSQSD
   241  MFDQRLQSKV LKLVDISYGG ENGFNQAIEL STEVLSNVKF IQEKKLIGRY FDEISQDTGK
   301  YCFGVEDTLK ALEMGAVEIL IVYENLDIMR YVLHCQGTEE EKILYLTPEQ EKDKSHFTDK
   361  ETGQEHELIE SMPLLEWFAN NYKKFGATLE IVTDKSQEGS QFVKGFGGIG GILRYRVDFQ
   421  GMEYQGGDDE FFDLDDY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ETF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
160 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 160 nTPM
  • skeletal muscle: 92 nTPM
  • esophagus: 83 nTPM
  • tongue: 69 nTPM
  • urinary bladder: 65 nTPM
  • adipose tissue: 64 nTPM

Single-cell type

  • neutrophils: 1,218 nCPM
  • early spermatids: 497 nCPM
  • esophageal apical cells: 433 nCPM
  • syncytiotrophoblasts: 416 nCPM
  • salivary myoepithelial cells: 322 nCPM
  • neutrophil progenitors: 307 nCPM

Immune cell

  • intermediate monocyte: 27 nTPM
  • non-classical monocyte: 26 nTPM
  • myeloid DC: 24 nTPM
  • classical monocyte: 23 nTPM
  • T-reg: 20 nTPM
  • MAIT T-cell: 20 nTPM

Brain region

  • choroid plexus: 53 nTPM
  • cerebral cortex: 46 nTPM
  • hypothalamus: 45 nTPM
  • thalamus: 44 nTPM
  • midbrain: 43 nTPM
  • white matter: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
1
gnomAD missense Z
4.39
DepMap mean gene effect
-1.78
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ETF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ETF1 as an antibody target. Whether an autoantibody or antibody against ETF1 could matter depends on whether native ETF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ETF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ETF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ETF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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