Seroatlas · Human Serome Atlas

CHCHD3

MICOS complex subunit MIC19

Also known as: FLJ20420, Mic19, MIC19_HUMAN, MICOS19, MINOS3, PPP1R22

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NX63
Gene
CHCHD3
Ensembl
ENSG00000106554
Chromosome
7
Canonical length
227 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

The protein encoded by this gene is an inner mitochondrial membrane scaffold protein. Absence of the encoded protein affects the structural integrity of mitochondrial cristae and leads to reductions in ATP production, cell growth, and oxygen consumption. This protein is part of the mitochondrial contact site and cristae organizing system (MICOS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

227 residues, UniProt reviewed canonical sequence.

>Q9NX63|CHCHD3
     1  MGGTTSTRRV TFEADENENI TVVKGIRLSE NVIDRMKESS PSGSKSQRYS GAYGASVSDE
    61  ELKRRVAEEL ALEQAKKESE DQKRLKQAKE LDRERAAANE QLTRAILRER ICSEEERAKA
   121  KHLARQLEEK DRVLKKQDAF YKEQLARLEE RSSEFYRVTT EQYQKAAEEV EAKFKRYESH
   181  PVCADLQAKI LQCYRENTHQ TLKCSALATQ YMHCVNHAKQ SMLEKGG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHCHD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
330 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 330 nTPM
  • tongue: 227 nTPM
  • heart muscle: 118 nTPM
  • parathyroid gland: 56 nTPM
  • duodenum: 53 nTPM
  • kidney: 51 nTPM

Single-cell type

  • myonuclei: 576 nCPM
  • choroid plexus epithelial cells: 391 nCPM
  • distal convoluted tubule cells: 340 nCPM
  • renal connecting tubule cells: 333 nCPM
  • renal collecting duct intercalated cells: 306 nCPM
  • enteric stem cells: 304 nCPM

Immune cell

  • intermediate monocyte: 63 nTPM
  • myeloid DC: 58 nTPM
  • non-classical monocyte: 52 nTPM
  • plasmacytoid DC: 50 nTPM
  • NK-cell: 45 nTPM
  • classical monocyte: 44 nTPM

Brain region

  • cerebral cortex: 43 nTPM
  • choroid plexus: 37 nTPM
  • cerebellum: 35 nTPM
  • white matter: 34 nTPM
  • hippocampal formation: 32 nTPM
  • medulla oblongata: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0.03
gnomAD missense Z
0.37
DepMap mean gene effect
-0.32
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHCHD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHCHD3 as an antibody target. Whether an autoantibody or antibody against CHCHD3 could matter depends on whether native CHCHD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHCHD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHCHD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHCHD3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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