Seroatlas · Human Serome Atlas

TSSK6

Testis-specific serine/threonine-protein kinase 6

Also known as: CT72, FLJ24002, SSTK, TSSK6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BXA6
Gene
TSSK6
Ensembl
ENSG00000178093
Chromosome
19
Canonical length
273 aa
Protein class
Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

273 residues, UniProt reviewed canonical sequence.

>Q9BXA6|TSSK6
     1  MSGDKLLSEL GYKLGRTIGE GSYSKVKVAT SKKYKGTVAI KVVDRRRAPP DFVNKFLPRE
    61  LSILRGVRHP HIVHVFEFIE VCNGKLYIVM EAAATDLLQA VQRNGRIPGV QARDLFAQIA
   121  GAVRYLHDHH LVHRDLKCEN VLLSPDERRV KLTDFGFGRQ AHGYPDLSTT YCGSAAYASP
   181  EVLLGIPYDP KKYDVWSMGV VLYVMVTGCM PFDDSDIAGL PRRQKRGVLY PEGLELSERC
   241  KALIAELLQF SPSARPSAGQ VARNCWLRAG DSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSSK6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
206 nTPM

Expression across tissuesHPA

Tissue

  • testis: 206 nTPM
  • skin: 1.5 nTPM
  • liver: 1.2 nTPM
  • spleen: 1.1 nTPM
  • pancreas: 1 nTPM
  • small intestine: 1 nTPM

Single-cell type

  • late spermatids: 18,237 nCPM
  • early spermatids: 1,642 nCPM
  • late primary spermatocytes: 206 nCPM
  • leydig cells: 26 nCPM
  • sertoli cells: 25 nCPM
  • undifferentiated spermatogonia: 22 nCPM

Immune cell

  • naive CD4 T-cell: 0.8 nTPM
  • memory B-cell: 0.7 nTPM
  • naive CD8 T-cell: 0.4 nTPM
  • eosinophil: 0.3 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM

Brain region

  • white matter: 2.9 nTPM
  • medulla oblongata: 2.5 nTPM
  • pons: 2.4 nTPM
  • midbrain: 2.2 nTPM
  • basal ganglia: 2.1 nTPM
  • spinal cord: 2.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TSSK6.

Disease | ImmuneIEDB

Conditions an epitope on TSSK6 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0.74
gnomAD missense Z
2.25
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSSK6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSSK6 as an antibody target. Whether an autoantibody or antibody against TSSK6 could matter depends on whether native TSSK6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSSK6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSSK6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TSSK6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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