ATF5
Cyclic AMP-dependent transcription factor ATF-5
Also known as: ATF5_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y2D1
- Gene
- ATF5
- Ensembl
- ENSG00000169136
- Chromosome
- 19
- Canonical length
- 282 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and tubulin binding activity. Involved in several processes, including fat cell differentiation; regulation of DNA-templated transcription; and regulation of cell cycle process. Located in centrosome; cytosol; and nucleoplasm. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
282 residues, UniProt reviewed canonical sequence.
>Q9Y2D1|ATF5
1 MSLLATLGLE LDRALLPASG LGWLVDYGKL PPAPAPLAPY EVLGGALEGG LPVGGEPLAG
61 DGFSDWMTER VDFTALLPLE PPLPPGTLPQ PSPTPPDLEA MASLLKKELE QMEDFFLDAP
121 PLPPPSPPPL PPPPLPPAPS LPLSLPSFDL PQPPVLDTLD LLAIYCRNEA GQEEVGMPPL
181 PPPQQPPPPS PPQPSRLAPY PHPATTRGDR KQKKRDQNKS AALRYRQRKR AEGEALEGEC
241 QGLEARNREL KERAESVERE IQYVKDLLIE VYKARSQRTR SCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ATF5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.63
- Highest tissue expression
- 2,375 nTPM
Expression across tissuesHPA
Tissue
- liver: 2,375 nTPM
- thyroid gland: 111 nTPM
- adrenal gland: 58 nTPM
- testis: 43 nTPM
- adipose tissue: 39 nTPM
- breast: 35 nTPM
Single-cell type
- hepatocytes: 1,267 nCPM
- early spermatids: 281 nCPM
- late spermatids: 180 nCPM
- late primary spermatocytes: 114 nCPM
- plasma cells: 112 nCPM
- cdc: 97 nCPM
Immune cell
- plasmacytoid DC: 30 nTPM
- intermediate monocyte: 18 nTPM
- classical monocyte: 18 nTPM
- myeloid DC: 12 nTPM
- non-classical monocyte: 5.3 nTPM
- total PBMC: 4.3 nTPM
Brain region
- midbrain: 31 nTPM
- pons: 28 nTPM
- medulla oblongata: 26 nTPM
- white matter: 26 nTPM
- hypothalamus: 25 nTPM
- spinal cord: 24 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.78
- gnomAD pLI
- 0.29
- gnomAD missense Z
- -0.34
- DepMap mean gene effect
- -0.11
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cerebellar granule cell precursor proliferation
- circadian rhythm
- fat cell differentiation
- multicellular organism growth
- negative regulation of apoptotic process
- negative regulation of cell cycle G2/M phase transition
- negative regulation of cell population proliferation
- negative regulation of DNA-templated transcription
- olfactory bulb interneuron development
- positive regulation of DNA-templated transcription
- positive regulation of transcription by RNA polymerase II
- post-embryonic development
- regulation of centrosome cycle
- regulation of DNA-templated transcription
- regulation of transcription by RNA polymerase II
Molecular functions
- chromatin binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- kinase binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- transcription cis-regulatory region binding
- tubulin binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ATF5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ATF5 as an antibody target. Whether an autoantibody or antibody against ATF5 could matter depends on whether native ATF5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ATF5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ATF5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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