Seroatlas · Human Serome Atlas

PGLYRP1

Peptidoglycan recognition protein 1

Also known as: PGLYRP, PGRP, PGRP-S, PGRP1_HUMAN, PGRPS, TAG7, TNFSF3L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75594
Gene
PGLYRP1
Ensembl
ENSG00000008438
Chromosome
19
Canonical length
196 aa
Protein class
Metabolic proteins, Plasma proteins, Predicted secreted proteins
Subcellular location
Nucleoplasm,Vesicles,Cytosol
Secretome location
Secreted to blood
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables several functions, including Hsp70 protein binding activity; peptidoglycan binding activity; and peptidoglycan immune receptor activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to Gram-positive bacterium; and detection of bacterium. Located in extracellular exosome. Is active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

196 residues, UniProt reviewed canonical sequence.

>O75594|PGLYRP1
     1  MSRRSMLLAW ALPSLLRLGA AQETEDPACC SPIVPRNEWK ALASECAQHL SLPLRYVVVS
    61  HTAGSSCNTP ASCQQQARNV QHYHMKTLGW CDVGYNFLIG EDGLVYEGRG WNFTGAHSGH
   121  LWNPMSIGIS FMGNYMDRVP TPQAIRAAQG LLACGVAQGA LRSNYVLKGH RDVQRTLSPG
   181  NQLYHLIQNW PHYRSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGLYRP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
595 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 595 nTPM
  • spleen: 42 nTPM
  • lung: 8.7 nTPM
  • thymus: 3.1 nTPM
  • liver: 2.5 nTPM
  • tongue: 2.1 nTPM

Single-cell type

  • neutrophil progenitors: 1,143 nCPM
  • neutrophils: 429 nCPM
  • retinal bipolar cells: 10 nCPM
  • platelets: 7 nCPM
  • erythrocytes: 6.1 nCPM
  • retinal horizontal cells: 6 nCPM

Immune cell

  • neutrophil: 497 nTPM
  • eosinophil: 445 nTPM
  • total PBMC: 3.9 nTPM
  • non-classical monocyte: 2.3 nTPM
  • classical monocyte: 0.4 nTPM
  • intermediate monocyte: 0.4 nTPM

Brain region

  • cerebellum: 20 nTPM
  • cerebral cortex: 17 nTPM
  • basal ganglia: 14 nTPM
  • hippocampal formation: 12 nTPM
  • amygdala: 11 nTPM
  • white matter: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.79
gnomAD pLI
0
gnomAD missense Z
0.53
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PGLYRP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PGLYRP1 as an antibody target. Whether an autoantibody or antibody against PGLYRP1 could matter depends on whether native PGLYRP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PGLYRP1 is annotated as secreted, so native PGLYRP1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • Involved in antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to Gram-positive bacterium; and detection of bacterium.

Canonical record: https://seroatlas.com/gene/PGLYRP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...