GNGT1
Guanine nucleotide-binding protein G(T) subunit gamma-T1
Also known as: GBG1_HUMAN, GNG1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P63211
- Gene
- GNGT1
- Ensembl
- ENSG00000127928
- Chromosome
- 7
- Canonical length
- 74 aa
- Protein class
- Predicted intracellular proteins, RAS pathway related proteins
OverviewNCBI Gene
This gene encodes the gamma subunit of transducin, a guanine nucleotide-binding protein (G protein) that is found in rod outer segments. Transducin, also known as GMPase, mediates the activation of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase by rhodopsin. [provided by RefSeq, Jul 2016]
Canonical amino-acid sequenceUniProt
74 residues, UniProt reviewed canonical sequence.
>P63211|GNGT1
1 MPVINIEDLT EKDKLKMEVD QLKKEVTLER MLVSKCCEEV RDYVEERSGE DPLVKGIPED
61 KNPFKELKGG CVISLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GNGT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 1,760 nTPM
Expression across tissuesHPA
Tissue
- retina: 1,760 nTPM
- choroid plexus: 11 nTPM
- placenta: 2.7 nTPM
- kidney: 0.4 nTPM
- ovary: 0.4 nTPM
- salivary gland: 0.4 nTPM
Single-cell type
- rod photoreceptor cells: 1,547 nCPM
- retinal pigment epithelial cells: 213 nCPM
- mesothelial cells: 187 nCPM
- epicardial cells: 175 nCPM
- distal convoluted tubule cells: 163 nCPM
- proximal tubule cells: 102 nCPM
Immune cell
- basophil: 0.3 nTPM
- gdT-cell: 0.1 nTPM
- MAIT T-cell: 0.1 nTPM
- memory CD4 T-cell: 0.1 nTPM
- memory CD8 T-cell: 0.1 nTPM
- naive CD4 T-cell: 0.1 nTPM
Brain region
- choroid plexus: 2.9 nTPM
- hypothalamus: 2.5 nTPM
- cerebellum: 2.1 nTPM
- white matter: 2.1 nTPM
- cerebral cortex: 1.9 nTPM
- medulla oblongata: 1.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.33
- gnomAD pLI
- 0.25
- gnomAD missense Z
- -0.62
- DepMap mean gene effect
- 0.16
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cardiac muscle cell apoptotic process
- cellular response to hypoxia
- eye photoreceptor cell development
- G protein-coupled receptor signaling pathway
- intracellular protein localization
- phototransduction
- signal transduction
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of GNGT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GNGT1 as an antibody target. Whether an autoantibody or antibody against GNGT1 could matter depends on whether native GNGT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GNGT1 is annotated at the cell surface, where native GNGT1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label GNGT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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