GNG7
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Also known as: FLJ00058, GBG7_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O60262
- Gene
- GNG7
- Ensembl
- ENSG00000176533
- Chromosome
- 19
- Canonical length
- 68 aa
- Protein class
- Predicted intracellular proteins, RAS pathway related proteins
OverviewNCBI Gene
Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and regulation of adenylate cyclase activity. Predicted to act upstream of or within behavioral fear response; locomotory behavior; and receptor guanylyl cyclase signaling pathway. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
68 residues, UniProt reviewed canonical sequence.
>O60262|GNG7
1 MSATNNIAQA RKLVEQLRIE AGIERIKVSK AASDLMSYCE QHARNDPLLV GVPASENPFK
61 DKKPCIILLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GNG7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 421 nTPM
Expression across tissuesHPA
Tissue
- basal ganglia: 421 nTPM
- spinal cord: 130 nTPM
- hippocampal formation: 96 nTPM
- midbrain: 83 nTPM
- amygdala: 83 nTPM
- cerebral cortex: 78 nTPM
Single-cell type
- plasma cells: 789 nCPM
- b-cells: 767 nCPM
- retinal horizontal cells: 369 nCPM
- somatotrophs: 352 nCPM
- oligodendrocytes: 338 nCPM
- microglia: 328 nCPM
Immune cell
- memory B-cell: 58 nTPM
- naive B-cell: 50 nTPM
- plasmacytoid DC: 48 nTPM
- neutrophil: 12 nTPM
- eosinophil: 8 nTPM
- myeloid DC: 6 nTPM
Brain region
- basal ganglia: 735 nTPM
- thalamus: 307 nTPM
- medulla oblongata: 187 nTPM
- cerebral cortex: 177 nTPM
- midbrain: 172 nTPM
- cerebellum: 165 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.39
- gnomAD pLI
- 0.5
- gnomAD missense Z
- 0.42
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- behavioral fear response
- G protein-coupled receptor signaling pathway
- locomotory behavior
- receptor guanylyl cyclase signaling pathway
- regulation of G protein-coupled receptor signaling pathway
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of GNG7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GNG7 as an antibody target. Whether an autoantibody or antibody against GNG7 could matter depends on whether native GNG7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GNG7 is annotated at the cell surface, where native GNG7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label GNG7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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