GNG12
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Also known as: GBG12_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UBI6
- Gene
- GNG12
- Ensembl
- ENSG00000172380
- Chromosome
- 1
- Canonical length
- 72 aa
- Protein class
- Predicted intracellular proteins, RAS pathway related proteins
- Subcellular location
- Mitochondria
OverviewNCBI Gene
Enables PDZ domain binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
72 residues, UniProt reviewed canonical sequence.
>Q9UBI6|GNG12
1 MSSKTASTNN IAQARRTVQQ LRLEASIERI KVSKASADLM SYCEEHARSD PLLIGIPTSE
61 NPFKDKKTCI ILLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GNG12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 115 nTPM
Expression across tissuesHPA
Tissue
- duodenum: 115 nTPM
- small intestine: 104 nTPM
- esophagus: 77 nTPM
- skin: 76 nTPM
- blood vessel: 76 nTPM
- kidney: 74 nTPM
Single-cell type
- esophageal apical cells: 641 nCPM
- enterocytes: 386 nCPM
- basal keratinocytes: 342 nCPM
- suprabasal keratinocytes: 318 nCPM
- ocular epithelial cells: 297 nCPM
- syncytiotrophoblasts: 296 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- midbrain: 54 nTPM
- medulla oblongata: 39 nTPM
- hypothalamus: 33 nTPM
- spinal cord: 31 nTPM
- white matter: 31 nTPM
- pons: 25 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.06
- gnomAD pLI
- 0.59
- gnomAD missense Z
- 0.67
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of GNG12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GNG12 as an antibody target. Whether an autoantibody or antibody against GNG12 could matter depends on whether native GNG12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GNG12 is annotated at the cell surface, where native GNG12 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label GNG12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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