Seroatlas · Human Serome Atlas

ANKRD9

Ankyrin repeat domain-containing protein 9

Also known as: ANKR9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96BM1
Gene: ANKRD9
Ensembl: ENSG00000156381
Chromosome: 14
Canonical length: 317 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables ubiquitin-like ligase-substrate adaptor activity. Involved in intracellular copper ion homeostasis; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Located in cytoplasmic vesicle and cytosol. Part of Cul5-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>Q96BM1|ANKRD9
     1  MPWDARRPGG GADGGPEASG AARSRAQKQC RKSSFAFYQA VRDLLPVWLL EDMRASEAFH
    61  WDERGRAAAY SPSEALLYAL VHDHQAYAHY LLATFPRRAL APPSAGFRCC AAPGPHVALA
   121  VRYNRVGILR RILRTLRDFP AEERARVLDR RGCSRVEGGG TSLHVACELA RPECLFLLLG
   181  HGASPGLRDG GGLTPLELLL RQLGRDAGAT PSAAGAPASA PGEPRQRRLL LLDLLALYTP
   241  VGAAGSARQE LLGDRPRWQR LLGEDKFQWL AGLAPPSLFA RAMQVLVTAI SPGRFPEALD
   301  ELPLPPFLQP LDLTGKG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 149 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 149 nTPM
heart muscle: 105 nTPM
duodenum: 47 nTPM
testis: 39 nTPM
small intestine: 31 nTPM
cerebral cortex: 29 nTPM

Single-cell type

platelets: 241 nCPM
early spermatids: 182 nCPM
colonocytes: 160 nCPM
enterocytes: 119 nCPM
esophageal apical cells: 116 nCPM
breast lactating cells: 90 nCPM

Immune cell

non-classical monocyte: 0.4 nTPM
basophil: 0.1 nTPM
neutrophil: 0.1 nTPM
NK-cell: 0.1 nTPM
T-reg: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 109 nTPM
thalamus: 98 nTPM
medulla oblongata: 97 nTPM
amygdala: 81 nTPM
spinal cord: 79 nTPM
choroid plexus: 78 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0.29
gnomAD missense Z: 1.9
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin-like ligase-substrate adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ankyrin repeat
Ankyrin repeat-containing domain superfamily
E3 Ligase Complex Components and Neurotoxins

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANKRD9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD9 as an antibody target. Whether an autoantibody or antibody against ANKRD9 could matter depends on whether native ANKRD9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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