Seroatlas · Human Serome Atlas

TMF1

TATA element modulatory factor

Also known as: ARA160, TMF, TMF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P82094
Gene
TMF1
Ensembl
ENSG00000144747
Chromosome
3
Canonical length
1093 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

Enables nuclear androgen receptor binding activity and transcription coactivator activity. Involved in androgen receptor signaling pathway and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1093 residues, UniProt reviewed canonical sequence.

>P82094|TMF1
     1  MSWFNASQLS SFAKQALSQA QKSIDRVLDI QEEEPSIWAE TIPYGEPGIS SPVSGGWDTS
    61  TWGLKSNTEP QSPPIASPKA ITKPVRRTVV DESENFFSAF LSPTDVQTIQ KSPVVSKPPA
   121  KSQRPEEEVK SSLHESLHIG QSRTPETTES QVKDSSLCVS GETLAAGTSS PKTEGKHEET
   181  VNKESDMKVP TVSLKVSESV IDVKTTMESI SNTSTQSLTA ETKDIALEPK EQKHEDRQSN
   241  TPSPPVSTFS SGTSTTSDIE VLDHESVISE SSASSRQETT DSKSSLHLMQ TSFQLLSASA
   301  CPEYNRLDDF QKLTESCCSS DAFERIDSFS VQSLDSRSVS EINSDDELSG KGYALVPIIV
   361  NSSTPKSKTV ESAEGKSEEV NETLVIPTEE AEMEESGRSA TPVNCEQPDI LVSSTPINEG
   421  QTVLDKVAEQ CEPAESQPEA LSEKEDVCKT VEFLNEKLEK REAQLLSLSK EKALLEEAFD
   481  NLKDEMFRVK EESSSISSLK DEFTQRIAEA EKKVQLACKE RDAAKKEIKN IKEELATRLN
   541  SSETADLLKE KDEQIRGLME EGEKLSKQQL HNSNIIKKLR AKDKENENMV AKLNKKVKEL
   601  EEELQHLKQV LDGKEEVEKQ HRENIKKLNS MVERQEKDLG RLQVDMDELE EKNRSIQAAL
   661  DSAYKELTDL HKANAAKDSE AQEAALSREM KAKEELSAAL EKAQEEARQQ QETLAIQVGD
   721  LRLALQRTEQ AAARKEDYLR HEIGELQQRL QEAENRNQEL SQSVSSTTRP LLRQIENLQA
   781  TLGSQTSSWE KLEKNLSDRL GESQTLLAAA VERERAATEE LLANKIQMSS MESQNSLLRQ
   841  ENSRFQAQLE SEKNRLCKLE DENNRYQVEL ENLKDEYVRT LEETRKEKTL LNSQLEMERM
   901  KVEQERKKAI FTQETIKEKE RKPFSVSSTP TMSRSSSISG VDMAGLQTSF LSQDESHDHS
   961  FGPMPISANG SNLYDAVRMG AGSSIIENLQ SQLKLREGEI THLQLEIGNL EKTRSIMAEE
  1021  LVKLTNQNDE LEEKVKEIPK LRTQLRDLDQ RYNTILQMYG EKAEEAEELR LDLEDVKNMY
  1081  KTQIDELLRQ SLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 25 nTPM
  • thyroid gland: 20 nTPM
  • testis: 18 nTPM
  • salivary gland: 16 nTPM
  • placenta: 16 nTPM
  • lymph node: 15 nTPM

Single-cell type

  • late spermatids: 891 nCPM
  • early spermatids: 523 nCPM
  • late primary spermatocytes: 289 nCPM
  • fallopian tube ciliated cells: 238 nCPM
  • endometrial ciliated cells: 229 nCPM
  • respiratory ciliated cells: 228 nCPM

Immune cell

  • neutrophil: 5.3 nTPM
  • eosinophil: 5.1 nTPM
  • basophil: 4.8 nTPM
  • non-classical monocyte: 3.5 nTPM
  • T-reg: 3.2 nTPM
  • gdT-cell: 3.1 nTPM

Brain region

  • choroid plexus: 28 nTPM
  • cerebellum: 15 nTPM
  • white matter: 15 nTPM
  • medulla oblongata: 14 nTPM
  • hypothalamus: 13 nTPM
  • thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0
gnomAD missense Z
0.42
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • TATA element modulatory factor 1, TATA binding
  • TATA element modulatory factor 1 DNA binding
  • Growth and transcription regulation protein
  • TATA element modulatory factor 1 TATA binding
  • TATA element modulatory factor 1 DNA binding

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMF1 as an antibody target. Whether an autoantibody or antibody against TMF1 could matter depends on whether native TMF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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