Seroatlas · Human Serome Atlas

GPBP1L1

Vasculin-like protein 1

Also known as: GPBL1_HUMAN, SP192

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HC44
Gene: GPBP1L1
Ensembl: ENSG00000159592
Chromosome: 1
Canonical length: 474 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Focal adhesion sites,Cytosol

OverviewNCBI Gene

Predicted to enable DNA binding activity and RNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

474 residues, UniProt reviewed canonical sequence.

>Q9HC44|GPBP1L1
     1  MAQHDFVPAW LNFSTPQSAK SPTATFEKHG EHLPRGEGRF GVSRRRHNSS DGFFNNGPLR
    61  TAGDSWHQPS LFRHDSVDSG VSKGAYAGIT GNPSGWHSSS RGHDGMSQRS GGGTGNHRHW
   121  NGSFHSRKGC AFQEKPPMEI REEKKEDKVE KLQFEEEDFP SLNPEAGKQH QPCRPIGTPS
   181  GVWENPPSAK QPSKMLVIKK VSKEDPAAAF SAAFTSPGSH HANGNKLSSV VPSVYKNLVP
   241  KPVPPPSKPN AWKANRMEHK SGSLSSSRES AFTSPISVTK PVVLASGAAL SSPKESPSST
   301  TPPIEISSSR LTKLTRRTTD RKSEFLKTLK DDRNGDFSEN RDCDKLEDLE DNSTPEPKEN
   361  GEEGCHQNGL ALPVVEEGEV LSHSLEAEHR LLKAMGWQEY PENDENCLPL TEDELKEFHM
   421  KTEQLRRNGF GKNGFLQSRS SSLFSPWRST CKAEFEDSDT ETSSSETSDD DAWK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPBP1L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

liver: 62 nTPM
rectum: 58 nTPM
testis: 54 nTPM
colon: 54 nTPM
small intestine: 53 nTPM
tongue: 51 nTPM

Single-cell type

neutrophil progenitors: 368 nCPM
esophageal apical cells: 332 nCPM
neutrophils: 271 nCPM
myonuclei: 263 nCPM
colonocytes: 204 nCPM
enterocytes: 193 nCPM

Immune cell

eosinophil: 40 nTPM
non-classical monocyte: 31 nTPM
intermediate monocyte: 27 nTPM
NK-cell: 27 nTPM
T-reg: 27 nTPM
basophil: 24 nTPM

Brain region

white matter: 46 nTPM
basal ganglia: 40 nTPM
midbrain: 38 nTPM
medulla oblongata: 38 nTPM
pons: 38 nTPM
thalamus: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.2
gnomAD missense Z: -0.13
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPBP1L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPBP1L1 as an antibody target. Whether an autoantibody or antibody against GPBP1L1 could matter depends on whether native GPBP1L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPBP1L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPBP1L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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