Seroatlas · Human Serome Atlas

BZW2

eIF5-mimic protein 1

Also known as: 5MP1, 5MP1_HUMAN, HSPC028, MST017, MSTP017

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y6E2
Gene: BZW2
Ensembl: ENSG00000136261
Chromosome: 7
Canonical length: 419 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Actin filaments,Cytosol

OverviewNCBI Gene

Enables cadherin binding activity. Involved in regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

419 residues, UniProt reviewed canonical sequence.

>Q9Y6E2|BZW2
     1  MNKHQKPVLT GQRFKTRKRD EKEKFEPTVF RDTLVQGLNE AGDDLEAVAK FLDSTGSRLD
    61  YRRYADTLFD ILVAGSMLAP GGTRIDDGDK TKMTNHCVFS ANEDHETIRN YAQVFNKLIR
   121  RYKYLEKAFE DEMKKLLLFL KAFSETEQTK LAMLSGILLG NGTLPATILT SLFTDSLVKE
   181  GIAASFAVKL FKAWMAEKDA NSVTSSLRKA NLDKRLLELF PVNRQSVDHF AKYFTDAGLK
   241  ELSDFLRVQQ SLGTRKELQK ELQERLSQEC PIKEVVLYVK EEMKRNDLPE TAVIGLLWTC
   301  IMNAVEWNKK EELVAEQALK HLKQYAPLLA VFSSQGQSEL ILLQKVQEYC YDNIHFMKAF
   361  QKIVVLFYKA DVLSEEAILK WYKEAHVAKG KSVFLDQMKK FVEWLQNAEE ESESEGEEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BZW2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 344 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 344 nTPM
heart muscle: 248 nTPM
tongue: 242 nTPM
retina: 81 nTPM
placenta: 76 nTPM
urinary bladder: 56 nTPM

Single-cell type

extravillous trophoblasts: 1,571 nCPM
syncytiotrophoblasts: 1,200 nCPM
migrating cytotrophoblasts: 496 nCPM
cytotrophoblasts: 329 nCPM
rod photoreceptor cells: 251 nCPM
urothelial cells: 246 nCPM

Immune cell

myeloid DC: 99 nTPM
naive CD4 T-cell: 57 nTPM
NK-cell: 57 nTPM
intermediate monocyte: 55 nTPM
naive CD8 T-cell: 47 nTPM
classical monocyte: 46 nTPM

Brain region

cerebral cortex: 21 nTPM
basal ganglia: 18 nTPM
choroid plexus: 17 nTPM
white matter: 15 nTPM
hippocampal formation: 13 nTPM
thalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.1
gnomAD missense Z: 1.95
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of translational initiation

Molecular functions

cadherin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BZW2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BZW2 as an antibody target. Whether an autoantibody or antibody against BZW2 could matter depends on whether native BZW2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BZW2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BZW2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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