Seroatlas · Human Serome Atlas

IFIT1

Antiviral innate immune response effector IFIT1

Also known as: G10P1, GARG-16, IFI56, IFIT1_HUMAN, IFNAI1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P09914
Gene
IFIT1
Ensembl
ENSG00000185745
Chromosome
10
Canonical length
478 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on chromosome 10 with five other closely related genes. There is a pseudogene for this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

478 residues, UniProt reviewed canonical sequence.

>P09914|IFIT1
     1  MSTNGDDHQV KDSLEQLRCH FTWELSIDDD EMPDLENRVL DQIEFLDTKY SVGIHNLLAY
    61  VKHLKGQNEE ALKSLKEAEN LMQEEHDNQA NVRSLVTWGN FAWMYYHMGR LAEAQTYLDK
   121  VENICKKLSN PFRYRMECPE IDCEEGWALL KCGGKNYERA KACFEKVLEV DPENPESSAG
   181  YAISAYRLDG FKLATKNHKP FSLLPLRQAV RLNPDNGYIK VLLALKLQDE GQEAEGEKYI
   241  EEALANMSSQ TYVFRYAAKF YRRKGSVDKA LELLKKALQE TPTSVLLHHQ IGLCYKAQMI
   301  QIKEATKGQP RGQNREKLDK MIRSAIFHFE SAVEKKPTFE VAHLDLARMY IEAGNHRKAE
   361  ENFQKLLCMK PVVEETMQDI HFHYGRFQEF QKKSDVNAII HYLKAIKIEQ ASLTRDKSIN
   421  SLKKLVLRKL RRKALDLESL SLLGFVYKLE GNMNEALEYY ERALRLAADF ENSVRQGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFIT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 40 nTPM
  • liver: 23 nTPM
  • tongue: 19 nTPM
  • choroid plexus: 19 nTPM
  • kidney: 18 nTPM
  • spleen: 18 nTPM

Single-cell type

  • müller glia: 76 nCPM
  • epididymal efferent duct ciliated cells: 64 nCPM
  • epididymal basal cells: 63 nCPM
  • hofbauer cells: 61 nCPM
  • epididymal clear cells: 41 nCPM
  • peritubular myoid cells: 40 nCPM

Immune cell

  • neutrophil: 67 nTPM
  • non-classical monocyte: 22 nTPM
  • intermediate monocyte: 16 nTPM
  • eosinophil: 15 nTPM
  • classical monocyte: 13 nTPM
  • basophil: 10 nTPM

Brain region

  • spinal cord: 55 nTPM
  • medulla oblongata: 24 nTPM
  • cerebellum: 24 nTPM
  • midbrain: 23 nTPM
  • white matter: 23 nTPM
  • hypothalamus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.53
gnomAD pLI
0
gnomAD missense Z
0.33
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFIT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFIT1 as an antibody target. Whether an autoantibody or antibody against IFIT1 could matter depends on whether native IFIT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFIT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFIT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IFIT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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