Seroatlas · Human Serome Atlas

IFIT2

Interferon-induced protein with tetratricopeptide repeats 2

Also known as: cig42, G10P2, GARG-39, IFI-54, IFI54, IFIT2_HUMAN, ISG-54, ISG-54K

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P09913
Gene
IFIT2
Ensembl
ENSG00000119922
Chromosome
10
Canonical length
472 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables RNA binding activity. Involved in antiviral innate immune response and positive regulation of apoptotic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

472 residues, UniProt reviewed canonical sequence.

>P09913|IFIT2
     1  MSENNKNSLE SSLRQLKCHF TWNLMEGENS LDDFEDKVFY RTEFQNREFK ATMCNLLAYL
    61  KHLKGQNEAA LECLRKAEEL IQQEHADQAE IRSLVTWGNY AWVYYHMGRL SDVQIYVDKV
   121  KHVCEKFSSP YRIESPELDC EEGWTRLKCG GNQNERAKVC FEKALEKKPK NPEFTSGLAI
   181  ASYRLDNWPP SQNAIDPLRQ AIRLNPDNQY LKVLLALKLH KMREEGEEEG EGEKLVEEAL
   241  EKAPGVTDVL RSAAKFYRRK DEPDKAIELL KKALEYIPNN AYLHCQIGCC YRAKVFQVMN
   301  LRENGMYGKR KLLELIGHAV AHLKKADEAN DNLFRVCSIL ASLHALADQY EDAEYYFQKE
   361  FSKELTPVAK QLLHLRYGNF QLYQMKCEDK AIHHFIEGVK INQKSREKEK MKDKLQKIAK
   421  MRLSKNGADS EALHVLAFLQ ELNEKMQQAD EDSERGLESG SLIPSASSWN GE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFIT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 46 nTPM
  • spinal cord: 28 nTPM
  • spleen: 26 nTPM
  • liver: 20 nTPM
  • lung: 20 nTPM
  • midbrain: 18 nTPM

Single-cell type

  • pdcs: 469 nCPM
  • epididymal clear cells: 241 nCPM
  • endometrial luminal cells: 171 nCPM
  • epididymal basal cells: 116 nCPM
  • kupffer cells: 77 nCPM
  • epididymal efferent duct ciliated cells: 63 nCPM

Immune cell

  • neutrophil: 421 nTPM
  • eosinophil: 108 nTPM
  • basophil: 98 nTPM
  • non-classical monocyte: 93 nTPM
  • intermediate monocyte: 76 nTPM
  • classical monocyte: 33 nTPM

Brain region

  • spinal cord: 55 nTPM
  • white matter: 33 nTPM
  • medulla oblongata: 32 nTPM
  • pons: 31 nTPM
  • basal ganglia: 27 nTPM
  • midbrain: 26 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IFIT2.

Disease | ImmuneIEDB

Conditions an epitope on IFIT2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0.25
gnomAD missense Z
0.52
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFIT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFIT2 as an antibody target. Whether an autoantibody or antibody against IFIT2 could matter depends on whether native IFIT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFIT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFIT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IFIT2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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