Seroatlas · Human Serome Atlas

ZFP36L2

mRNA decay activator protein ZFP36L2

Also known as: BRF2, ERF2, RNF162C, TIS11D, TISD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P47974
Gene: ZFP36L2
Ensembl: ENSG00000152518
Chromosome: 2
Canonical length: 494 aa
Protein class: Cancer-related genes, Disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

494 residues, UniProt reviewed canonical sequence.

>P47974|ZFP36L2
     1  MSTTLLSAFY DVDFLCKTEK SLANLNLNNM LDKKAVGTPV AAAPSSGFAP GFLRRHSASN
    61  LHALAHPAPS PGSCSPKFPG AANGSSCGSA AAGGPTSYGT LKEPSGGGGT ALLNKENKFR
   121  DRSFSENGDR SQHLLHLQQQ QKGGGGSQIN STRYKTELCR PFEESGTCKY GEKCQFAHGF
   181  HELRSLTRHP KYKTELCRTF HTIGFCPYGP RCHFIHNADE RRPAPSGGAS GDLRAFGTRD
   241  ALHLGFPREP RPKLHHSLSF SGFPSGHHQP PGGLESPLLL DSPTSRTPPP PSCSSASSCS
   301  SSASSCSSAS AASTPSGAPT CCASAAAAAA AALLYGTGGA EDLLAPGAPC AACSSASCAN
   361  NAFAFGPELS SLITPLAIQT HNFAAVAAAA YYRSQQQQQQ QGLAPPAQPP APPSATLPAG
   421  AAAPPSPPFS FQLPRRLSDS PVFDAPPSPP DSLSDRDSYL SGSLSSGSLS GSESPSLDPG
   481  RRLPIFSRLS ISDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFP36L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 208 nTPM

Expression across tissuesHPA

Tissue

skin: 208 nTPM
bone marrow: 184 nTPM
adipose tissue: 177 nTPM
ovary: 176 nTPM
thyroid gland: 171 nTPM
blood vessel: 169 nTPM

Single-cell type

innate lymphoid cells: 1,799 nCPM
t-cells: 1,567 nCPM
epididymal basal cells: 1,553 nCPM
basal keratinocytes: 1,314 nCPM
hematopoietic stem cells: 1,272 nCPM
nk-cells: 1,002 nCPM

Immune cell

eosinophil: 82 nTPM
memory CD8 T-cell: 63 nTPM
neutrophil: 62 nTPM
NK-cell: 53 nTPM
myeloid DC: 51 nTPM
gdT-cell: 47 nTPM

Brain region

medulla oblongata: 225 nTPM
spinal cord: 118 nTPM
pons: 102 nTPM
thalamus: 101 nTPM
midbrain: 99 nTPM
hypothalamus: 90 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZFP36L2.

Disease | AllUniProt

Conditions ZFP36L2 is implicated in, by any mechanism.

Oocyte/zygote/embryo maturation arrest 13 (OZEMA13) MIM:620154

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 131 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Oocyte maturation defect 13

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.97
gnomAD missense Z: -1.84
DepMap mean gene effect: -0.31
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZFP36L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFP36L2 as an antibody target. Whether an autoantibody or antibody against ZFP36L2 could matter depends on whether native ZFP36L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFP36L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFP36L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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