Seroatlas · Human Serome Atlas

NANOS2

Nanos homolog 2

Also known as: NANO2_HUMAN, NOS2, ZC2HC12B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P60321
Gene: NANOS2
Ensembl: ENSG00000188425
Chromosome: 19
Canonical length: 138 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables enzyme activator activity. Involved in mRNA destabilization and negative regulation of translation. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

138 residues, UniProt reviewed canonical sequence.

>P60321|NANOS2
     1  MQLPPFDMWK DYFNLSQVVW ALIASRGQRL ETQEIEEPSP GPPLGQDQGL GAPGANGGLG
    61  TLCNFCKHNG ESRHVYSSHQ LKTPDGVVVC PILRHYVCPV CGATGDQAHT LKYCPLNGGQ
   121  QSLYRRSGRN SAGRRVKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NANOS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 3.6 nTPM

Expression across tissuesHPA

Tissue

testis: 3.6 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM
cerebral cortex: 0.1 nTPM
hippocampal formation: 0.1 nTPM
hypothalamus: 0.1 nTPM

Single-cell type

undifferentiated spermatogonia: 19 nCPM
late primary spermatocytes: 1.4 nCPM
differentiating spermatogonia: 0.9 nCPM
retinal amacrine cells: 0.7 nCPM
early spermatids: 0.4 nCPM
retinal bipolar cells: 0.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.8 nTPM
white matter: 0.4 nTPM
basal ganglia: 0.3 nTPM
hippocampal formation: 0.3 nTPM
medulla oblongata: 0.3 nTPM
pons: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.65
gnomAD pLI: 0.05
gnomAD missense Z: 0.48
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NANOS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NANOS2 as an antibody target. Whether an autoantibody or antibody against NANOS2 could matter depends on whether native NANOS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NANOS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NANOS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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