Ribonuclease CAF1
IPR006941
Definition
The major pathways of mRNA turnover in eukaryotes initiate with shortening of the poly(A) tail. CAF1 (also known as CCR4-associated factor 1) is an RNase of the DEDD superfamily, and a subunit of the CCR4-NOT complex that mediates 3' to 5' mRNA deadenylation [[cite:PMID:15215893], [cite:PMID:15769875]]. In yeast, CAF1 ([swissprot:P39008]) is also known as POP2, and encodes a critical component of the major cytoplasmic deadenylase [[cite:PMID:11410650], [cite:PMID:11239395]]. It is required for normal mRNA deadenylationin vivoand localises to the cytoplasm. CAF1 copurifies with a CCR4-dependent poly(A)-specific exonuclease activity. The crystal structure of Saccharomyces cerevisiae POP2 has been resolved PMID:14618157. Some members of this family contain a single-stranded nucleic acid binding domain, R3H, such as poly(A)-specific ribonuclease (PARN), which also contains an RRM domain PMID:23388391. PARN is only conserved in vertebrates and may be important in regulated deadenylation such as early developmentand DNA damage response [[cite:PMID:15247430], [cite:PMID:20379136]].
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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