CAF1 family ribonuclease
PF04857
Definition
The major pathways of mRNA turnover in eukaryotes initiate with shortening of the polyA tail. CAF1 [swissprot:P39008] encodes a critical component of the major cytoplasmic deadenylase in yeast. Both Caf1p is required for normal mRNA deadenylation in vivo and localises to the cytoplasm. Caf1p copurifies with a Ccr4p-dependent polyA-specific exonuclease activity. Some members of this family include and inserted RNA binding domain [pfam:PF01424]. This family of proteins is related to other exonucleases [pfam:PF00929] (Bateman A pers. obs.). The crystal structure of Saccharomyces cerevisiae Pop2 ([swissprot:P39008]) has been resolved at 2.3 Angstrom resolution PMID:14618157.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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